Enhancing radiotherapy outcomes in rectal cancer: A systematic review of targeting hypoxia-induced radioresistance

Enhancing radiotherapy outcomes in rectal cancer: A systematic review of targeting hypoxia-induced radioresistance

Introduction: Neoadjuvant radiotherapy is successfully used in rectal cancer to improve overall survival. However, treatment response is both unpredictable and variable. There is strong evidence to show that the phenomenon of tumour hypoxia is associated with radioresistance, however the mechanism(s...

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Bibliographic Details
Main Authors: Matthew Fok, Rhianna Hill, Hayley Fowler, Rachael Clifford, Aaron Kler, Jayanma Uzzi-Daniel, Sonia Rocha, Gabrielle Grundy, Jason Parsons, Dale Vimalachandran
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Clinical and Translational Radiation Oncology
Subjects:
Rectal cancer
Tumour hypoxia
Radiotherapy
Hypoxia
Online Access:http://www.sciencedirect.com/science/article/pii/S2405630823001209

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