Efficacy and Effect of Inhaled Adenosine Treatment in Hospitalized COVID-19 Patients
Lack of specific antiviral treatment for COVID-19 has resulted in long hospitalizations and high mortality rate. By harnessing the regulatory effects of adenosine on inflammatory mediators, we have instituted a new therapeutic treatment with inhaled adenosine in COVID-19 patients, with the aim of re...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.613070/full |
| _version_ | 1818615308313690112 |
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| author | Massimo Caracciolo Pierpaolo Correale Carmelo Mangano Giuseppe Foti Carmela Falcone Sebastiano Macheda Maria Cuzzola Marco Conte Antonella Consuelo Falzea Eleonora Iuliano Antonella Morabito Michele Caraglia Michele Caraglia Nicola Polimeni Anna Ferrarelli Demetrio Labate Marco Tescione Laura Di Renzo Gaetano Chiricolo Lorenzo Romano Antonino De Lorenzo |
| author_facet | Massimo Caracciolo Pierpaolo Correale Carmelo Mangano Giuseppe Foti Carmela Falcone Sebastiano Macheda Maria Cuzzola Marco Conte Antonella Consuelo Falzea Eleonora Iuliano Antonella Morabito Michele Caraglia Michele Caraglia Nicola Polimeni Anna Ferrarelli Demetrio Labate Marco Tescione Laura Di Renzo Gaetano Chiricolo Lorenzo Romano Antonino De Lorenzo |
| author_sort | Massimo Caracciolo |
| collection | DOAJ |
| description | Lack of specific antiviral treatment for COVID-19 has resulted in long hospitalizations and high mortality rate. By harnessing the regulatory effects of adenosine on inflammatory mediators, we have instituted a new therapeutic treatment with inhaled adenosine in COVID-19 patients, with the aim of reducing inflammation, the onset of cytokine storm, and therefore to improve prognosis. The use of inhaled adenosine in COVID19 patients has allowed reduction of length of stay, on average 6 days. This result is strengthened by the decrease in SARS-CoV-2 positive days. In treated patients compared to control, a clear improvement in PaO2/FiO2 was observed together with a reduction in inflammation parameters, such as the decrease of CRP level. Furthermore, the efficacy of inhaled exogenous adenosine led to an improvement of the prognosis indices, NLR and PLR. The treatment seems to be safe and modulates the immune system, allowing an effective response against the viral infection progression, reducing length of stay and inflammation parameters. |
| first_indexed | 2024-12-16T16:31:50Z |
| format | Article |
| id | doaj.art-05c5ea14673c410a88457a775b784ddb |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-16T16:31:50Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-05c5ea14673c410a88457a775b784ddb2022-12-21T22:24:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-03-011210.3389/fimmu.2021.613070613070Efficacy and Effect of Inhaled Adenosine Treatment in Hospitalized COVID-19 PatientsMassimo Caracciolo0Pierpaolo Correale1Carmelo Mangano2Giuseppe Foti3Carmela Falcone4Sebastiano Macheda5Maria Cuzzola6Marco Conte7Antonella Consuelo Falzea8Eleonora Iuliano9Antonella Morabito10Michele Caraglia11Michele Caraglia12Nicola Polimeni13Anna Ferrarelli14Demetrio Labate15Marco Tescione16Laura Di Renzo17Gaetano Chiricolo18Lorenzo Romano19Antonino De Lorenzo20Unit of Post-Surgery Intensive Therapy (USDO), Grand Metropolitan Hospital, Reggio Calabria, ItalyMedical Oncology Unit, Grand Metropolitan Hospital, Reggio Calabria, ItalyUnit of Infectious Disease, Grand Metropolitan Hospital, Reggio Calabria, ItalyUnit of Infectious Disease, Grand Metropolitan Hospital, Reggio Calabria, ItalyUnit of Radiology, Grand Metropolitan Hospital, Reggio Calabria, ItalyUnit of Intensive Care Medicine and Anaesthesia, Grand Metropolitan Hospital, Reggio Calabria, ItalyMicrobiology Unit, Grand Metropolitan Hospital, Reggio Calabria, ItalyMicrobiology Unit, Grand Metropolitan Hospital, Reggio Calabria, ItalyMedical Oncology Unit, Grand Metropolitan Hospital, Reggio Calabria, ItalyMedical Oncology Unit, Grand Metropolitan Hospital, Reggio Calabria, ItalyUnit of Pharmacy, Grand Metropolitan Hospital, Reggio Calabria, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, Naples, ItalyBiogem Scarl, Institute of Genetic Research, Laboratory of Precision and Molecular Oncology, Ariano Irpino, ItalyUnit of Intensive Care Medicine and Anaesthesia, Grand Metropolitan Hospital, Reggio Calabria, ItalyUnit of Radiology, Grand Metropolitan Hospital, Reggio Calabria, ItalyUnit of Intensive Care Medicine and Anaesthesia, Grand Metropolitan Hospital, Reggio Calabria, ItalyUnit of Intensive Care Medicine and Anaesthesia, Grand Metropolitan Hospital, Reggio Calabria, Italy0Section of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy1Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy2PhD School of Applied Medical, Surgical Sciences, University of Rome Tor Vergata, Rome, Italy0Section of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, ItalyLack of specific antiviral treatment for COVID-19 has resulted in long hospitalizations and high mortality rate. By harnessing the regulatory effects of adenosine on inflammatory mediators, we have instituted a new therapeutic treatment with inhaled adenosine in COVID-19 patients, with the aim of reducing inflammation, the onset of cytokine storm, and therefore to improve prognosis. The use of inhaled adenosine in COVID19 patients has allowed reduction of length of stay, on average 6 days. This result is strengthened by the decrease in SARS-CoV-2 positive days. In treated patients compared to control, a clear improvement in PaO2/FiO2 was observed together with a reduction in inflammation parameters, such as the decrease of CRP level. Furthermore, the efficacy of inhaled exogenous adenosine led to an improvement of the prognosis indices, NLR and PLR. The treatment seems to be safe and modulates the immune system, allowing an effective response against the viral infection progression, reducing length of stay and inflammation parameters.https://www.frontiersin.org/articles/10.3389/fimmu.2021.613070/fulladenosineCOVID-19SARS-CoV-2length of stayinflammation |
| spellingShingle | Massimo Caracciolo Pierpaolo Correale Carmelo Mangano Giuseppe Foti Carmela Falcone Sebastiano Macheda Maria Cuzzola Marco Conte Antonella Consuelo Falzea Eleonora Iuliano Antonella Morabito Michele Caraglia Michele Caraglia Nicola Polimeni Anna Ferrarelli Demetrio Labate Marco Tescione Laura Di Renzo Gaetano Chiricolo Lorenzo Romano Antonino De Lorenzo Efficacy and Effect of Inhaled Adenosine Treatment in Hospitalized COVID-19 Patients Frontiers in Immunology adenosine COVID-19 SARS-CoV-2 length of stay inflammation |
| title | Efficacy and Effect of Inhaled Adenosine Treatment in Hospitalized COVID-19 Patients |
| title_full | Efficacy and Effect of Inhaled Adenosine Treatment in Hospitalized COVID-19 Patients |
| title_fullStr | Efficacy and Effect of Inhaled Adenosine Treatment in Hospitalized COVID-19 Patients |
| title_full_unstemmed | Efficacy and Effect of Inhaled Adenosine Treatment in Hospitalized COVID-19 Patients |
| title_short | Efficacy and Effect of Inhaled Adenosine Treatment in Hospitalized COVID-19 Patients |
| title_sort | efficacy and effect of inhaled adenosine treatment in hospitalized covid 19 patients |
| topic | adenosine COVID-19 SARS-CoV-2 length of stay inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.613070/full |
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