The Preparation of Curcumin-Loaded Pickering Emulsion Using Gelatin–Chitosan Colloidal Particles as Emulsifier for Possible Application as a Bio-Inspired Cosmetic Formulation
In the field of preparing cosmetic formulations, recent advances recommend the usage of excipients derived from biocompatible materials. In this context, the present study aimed to prepare and characterize the curcumin-loaded Pickering emulsion for possible applications in cosmetic formulation. The...
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| Format: | Article |
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MDPI AG
2024-03-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/16/3/356 |
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| author | Beena G. Singh Nalin Bagora Minati Nayak Juby K. Ajish Nitish Gupta Amit Kunwar |
| author_facet | Beena G. Singh Nalin Bagora Minati Nayak Juby K. Ajish Nitish Gupta Amit Kunwar |
| author_sort | Beena G. Singh |
| collection | DOAJ |
| description | In the field of preparing cosmetic formulations, recent advances recommend the usage of excipients derived from biocompatible materials. In this context, the present study aimed to prepare and characterize the curcumin-loaded Pickering emulsion for possible applications in cosmetic formulation. The coconut oil which is often the component of skin care formulations is used as the oily phase. Curcumin, which is well known for absorbing solar radiation, is expected to work synergistically with coconut oil towards improving the sun protection factor (SPF) of the formulation. Additionally, curcumin can also protect the intracellular components through its well-known antioxidant mechanisms. The Pickering emulsion of coconut oil into water was prepared using the composite colloidal particles derived from β-carboxymethyl chitosan (CMC) and Gelatin-A (GA) as the emulsifying agent. The reaction conditions in terms of the weight ratios of CMC and GA, the pH of the reaction medium, the oil volume fraction, and the homogenization speed were optimized to obtain the most stable Pickering emulsion. The obtained systems were physico-chemically characterized by dynamic light scattering, zeta potential, optical microscopy, and rheometric measurements. The final CMC-GA-stabilized emulsion demonstrated an oil droplet size of 100 µm and a SPF<sub>spectrophotometric (290–320 nm)</sub> value of 8.5 at a curcumin loading of 4 mg/mL. Additionally, the final formulation facilitated the uptake of curcumin into fibroblast (WI26) cells under in vitro conditions. Together, the investigation demonstrates a bio-inspired approach to prepare a curcumin-loaded green Pickering emulsion using biocompatible pharmaceutical grade excipients, which may find utility in cosmetic applications. |
| first_indexed | 2024-04-24T17:54:35Z |
| format | Article |
| id | doaj.art-05c7a8c5f8df482fbea97908020cf91e |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-24T17:54:35Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-05c7a8c5f8df482fbea97908020cf91e2024-03-27T13:59:42ZengMDPI AGPharmaceutics1999-49232024-03-0116335610.3390/pharmaceutics16030356The Preparation of Curcumin-Loaded Pickering Emulsion Using Gelatin–Chitosan Colloidal Particles as Emulsifier for Possible Application as a Bio-Inspired Cosmetic FormulationBeena G. Singh0Nalin Bagora1Minati Nayak2Juby K. Ajish3Nitish Gupta4Amit Kunwar5Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, IndiaDepartment of Applied Chemistry, S. G. S. Institute of Technology and Science, Indore 452003, IndiaRadiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, IndiaRadiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, IndiaDepartment of Applied Chemistry, S. G. S. Institute of Technology and Science, Indore 452003, IndiaRadiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, IndiaIn the field of preparing cosmetic formulations, recent advances recommend the usage of excipients derived from biocompatible materials. In this context, the present study aimed to prepare and characterize the curcumin-loaded Pickering emulsion for possible applications in cosmetic formulation. The coconut oil which is often the component of skin care formulations is used as the oily phase. Curcumin, which is well known for absorbing solar radiation, is expected to work synergistically with coconut oil towards improving the sun protection factor (SPF) of the formulation. Additionally, curcumin can also protect the intracellular components through its well-known antioxidant mechanisms. The Pickering emulsion of coconut oil into water was prepared using the composite colloidal particles derived from β-carboxymethyl chitosan (CMC) and Gelatin-A (GA) as the emulsifying agent. The reaction conditions in terms of the weight ratios of CMC and GA, the pH of the reaction medium, the oil volume fraction, and the homogenization speed were optimized to obtain the most stable Pickering emulsion. The obtained systems were physico-chemically characterized by dynamic light scattering, zeta potential, optical microscopy, and rheometric measurements. The final CMC-GA-stabilized emulsion demonstrated an oil droplet size of 100 µm and a SPF<sub>spectrophotometric (290–320 nm)</sub> value of 8.5 at a curcumin loading of 4 mg/mL. Additionally, the final formulation facilitated the uptake of curcumin into fibroblast (WI26) cells under in vitro conditions. Together, the investigation demonstrates a bio-inspired approach to prepare a curcumin-loaded green Pickering emulsion using biocompatible pharmaceutical grade excipients, which may find utility in cosmetic applications.https://www.mdpi.com/1999-4923/16/3/356colloidal particlescellular uptakegreen formulationpolyelectrolyterheologysun protection factor |
| spellingShingle | Beena G. Singh Nalin Bagora Minati Nayak Juby K. Ajish Nitish Gupta Amit Kunwar The Preparation of Curcumin-Loaded Pickering Emulsion Using Gelatin–Chitosan Colloidal Particles as Emulsifier for Possible Application as a Bio-Inspired Cosmetic Formulation Pharmaceutics colloidal particles cellular uptake green formulation polyelectrolyte rheology sun protection factor |
| title | The Preparation of Curcumin-Loaded Pickering Emulsion Using Gelatin–Chitosan Colloidal Particles as Emulsifier for Possible Application as a Bio-Inspired Cosmetic Formulation |
| title_full | The Preparation of Curcumin-Loaded Pickering Emulsion Using Gelatin–Chitosan Colloidal Particles as Emulsifier for Possible Application as a Bio-Inspired Cosmetic Formulation |
| title_fullStr | The Preparation of Curcumin-Loaded Pickering Emulsion Using Gelatin–Chitosan Colloidal Particles as Emulsifier for Possible Application as a Bio-Inspired Cosmetic Formulation |
| title_full_unstemmed | The Preparation of Curcumin-Loaded Pickering Emulsion Using Gelatin–Chitosan Colloidal Particles as Emulsifier for Possible Application as a Bio-Inspired Cosmetic Formulation |
| title_short | The Preparation of Curcumin-Loaded Pickering Emulsion Using Gelatin–Chitosan Colloidal Particles as Emulsifier for Possible Application as a Bio-Inspired Cosmetic Formulation |
| title_sort | preparation of curcumin loaded pickering emulsion using gelatin chitosan colloidal particles as emulsifier for possible application as a bio inspired cosmetic formulation |
| topic | colloidal particles cellular uptake green formulation polyelectrolyte rheology sun protection factor |
| url | https://www.mdpi.com/1999-4923/16/3/356 |
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