Rhamnetin Prevents Bradykinin-Induced Expression of Matrix Metalloproteinase-9 in Rat Brain Astrocytes by Suppressing Protein Kinase-Dependent AP-1 Activation

Rhamnetin Prevents Bradykinin-Induced Expression of Matrix Metalloproteinase-9 in Rat Brain Astrocytes by Suppressing Protein Kinase-Dependent AP-1 Activation

Bradykinin (BK) has been recognized as a stimulant for matrix metalloproteinase (MMP)-9 expression, contributing to neuroinflammation. Modulating the BK/MMP-9 pathway offers potential in the treatment of neuroinflammatory disorders. Rhamnetin (RNT), a flavonoid compound known for its antioxidant and...

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Bibliographic Details
Main Authors: Chuen-Mao Yang, I-Ta Lee, Li-Der Hsiao, Zih-Yao Yu, Chien-Chung Yang
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Biomedicines
Subjects:
neuroinflammation
rhamnetin
bradykinin
protein tyrosine kinases
matrix metalloproteinase-9
astrocytes
Online Access:https://www.mdpi.com/2227-9059/11/12/3198

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