PHARMACOLOGIC TOPOISOMERASE-I INHIBITION CAUSES DNA DAMAGE AND MORTALITY IN ACTIVATED CD4+ T CELLS
Topoisomerase-I is required for DNA replication. It acts by preventing torsional stress caused by DNA winding during replication fork progression. Topoisomerase-I inhibitors are widely used in many cancer therapies, in light of their anti-proliferative activity. However, their use as chemotherapeu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
University of Sarajevo, Institute for Genetic Engineering and Biotechnology
2018-12-01
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| Series: | Genetics & Applications |
| Subjects: | |
| Online Access: | https://genapp.ba/editions/index.php/journal/article/view/108 |