PHARMACOLOGIC TOPOISOMERASE-I INHIBITION CAUSES DNA DAMAGE AND MORTALITY IN ACTIVATED CD4+ T CELLS

PHARMACOLOGIC TOPOISOMERASE-I INHIBITION CAUSES DNA DAMAGE AND MORTALITY IN ACTIVATED CD4+ T CELLS

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Topoisomerase-I is required for DNA replication. It acts by preventing torsional stress caused by DNA winding during replication fork progression.  Topoisomerase-I inhibitors are widely used in many cancer therapies, in light of their anti-proliferative activity. However, their use as chemotherapeu...

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Bibliographic Details
Main Authors: Mia Stanić, Iart Luca Shytaj, Marina Lusic
Format: Article
Language:English
Published: University of Sarajevo, Institute for Genetic Engineering and Biotechnology 2018-12-01
Series:Genetics & Applications
Subjects:
Topoisomerase-I
topotecan
H2AX
CD4 T cells
Online Access:https://genapp.ba/editions/index.php/journal/article/view/108

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