An Amyloidogenic Sequence at the N-Terminus of the Androgen Receptor Impacts Polyglutamine Aggregation

An Amyloidogenic Sequence at the N-Terminus of the Androgen Receptor Impacts Polyglutamine Aggregation

The human androgen receptor (AR) is a ligand inducible transcription factor that harbors an amino terminal domain (AR-NTD) with a ligand-independent activation function. AR-NTD is intrinsically disordered and displays aggregation properties conferred by the presence of a poly-glutamine (polyQ) seque...

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Bibliographic Details
Main Authors: Emmanuel Oppong, Gunter Stier, Miriam Gaal, Rebecca Seeger, Melanie Stoeck, Marc-André Delsuc, Andrew C. B. Cato, Bruno Kieffer
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:Biomolecules
Subjects:
amyloid peptides
androgen receptor
nuclear receptor
aggregation
atomic force microscopy
Online Access:http://www.mdpi.com/2218-273X/7/2/44

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