Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues
Squamous cell carcinomas are an aggressive cancer type which can occur in multiple organ systems. Here, the authors analyse the proteome of SCC cancers from 17 organs and show commonly dysregulated proteins independent of location.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31719-0 |
| _version_ | 1811287352017944576 |
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| author | Qi Song Ye Yang Dongxian Jiang Zhaoyu Qin Chen Xu Haixing Wang Jie Huang Lingli Chen Rongkui Luo Xiaolei Zhang Yufeng Huang Lei Xu Zixiang Yu Subei Tan Minying Deng Ruqun Xue Jingbo Qie Kai Li Yanan Yin Xuetong Yue Xiaogang Sun Jieakesu Su Fuchu He Chen Ding Yingyong Hou |
| author_facet | Qi Song Ye Yang Dongxian Jiang Zhaoyu Qin Chen Xu Haixing Wang Jie Huang Lingli Chen Rongkui Luo Xiaolei Zhang Yufeng Huang Lei Xu Zixiang Yu Subei Tan Minying Deng Ruqun Xue Jingbo Qie Kai Li Yanan Yin Xuetong Yue Xiaogang Sun Jieakesu Su Fuchu He Chen Ding Yingyong Hou |
| author_sort | Qi Song |
| collection | DOAJ |
| description | Squamous cell carcinomas are an aggressive cancer type which can occur in multiple organ systems. Here, the authors analyse the proteome of SCC cancers from 17 organs and show commonly dysregulated proteins independent of location. |
| first_indexed | 2024-04-13T03:17:03Z |
| format | Article |
| id | doaj.art-05d0671cbe88464bab2dc69a85f38421 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T03:17:03Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-05d0671cbe88464bab2dc69a85f384212022-12-22T03:04:52ZengNature PortfolioNature Communications2041-17232022-07-0113112010.1038/s41467-022-31719-0Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissuesQi Song0Ye Yang1Dongxian Jiang2Zhaoyu Qin3Chen Xu4Haixing Wang5Jie Huang6Lingli Chen7Rongkui Luo8Xiaolei Zhang9Yufeng Huang10Lei Xu11Zixiang Yu12Subei Tan13Minying Deng14Ruqun Xue15Jingbo Qie16Kai Li17Yanan Yin18Xuetong Yue19Xiaogang Sun20Jieakesu Su21Fuchu He22Chen Ding23Yingyong Hou24Department of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversityState Key Laboratory Cell Differentiation and Regulation, Overseas Expertise Introduction Center for Discipline Innovation of Pulmonary Fibrosis, (111 Project), College of Life Science, Henan Normal UniversityDepartment of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversityState Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of LifeomicsDepartment of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Fudan UniversitySquamous cell carcinomas are an aggressive cancer type which can occur in multiple organ systems. Here, the authors analyse the proteome of SCC cancers from 17 organs and show commonly dysregulated proteins independent of location.https://doi.org/10.1038/s41467-022-31719-0 |
| spellingShingle | Qi Song Ye Yang Dongxian Jiang Zhaoyu Qin Chen Xu Haixing Wang Jie Huang Lingli Chen Rongkui Luo Xiaolei Zhang Yufeng Huang Lei Xu Zixiang Yu Subei Tan Minying Deng Ruqun Xue Jingbo Qie Kai Li Yanan Yin Xuetong Yue Xiaogang Sun Jieakesu Su Fuchu He Chen Ding Yingyong Hou Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues Nature Communications |
| title | Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues |
| title_full | Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues |
| title_fullStr | Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues |
| title_full_unstemmed | Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues |
| title_short | Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues |
| title_sort | proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues |
| url | https://doi.org/10.1038/s41467-022-31719-0 |
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