Involvement of Virus-Induced Interferon Production in IgG Autoantibody-Mediated Anemia
Infection with viruses, such as the lactate dehydrogenase-elevating virus (LDV), is known to trigger the onset of autoimmune anemia through the enhancement of the phagocytosis of autoantibody-opsonized erythrocytes by activated macrophages. Type I interferon receptor-deficient mice show enhanced ane...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/16/9027 |
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| author | Sarah Legrain Dan Su Mélanie Gaignage Cor Breukel Jill Claassens Conny Brouwers Margot M. Linssen Shozo Izui J. Sjef Verbeek Jean-Paul Coutelier |
| author_facet | Sarah Legrain Dan Su Mélanie Gaignage Cor Breukel Jill Claassens Conny Brouwers Margot M. Linssen Shozo Izui J. Sjef Verbeek Jean-Paul Coutelier |
| author_sort | Sarah Legrain |
| collection | DOAJ |
| description | Infection with viruses, such as the lactate dehydrogenase-elevating virus (LDV), is known to trigger the onset of autoimmune anemia through the enhancement of the phagocytosis of autoantibody-opsonized erythrocytes by activated macrophages. Type I interferon receptor-deficient mice show enhanced anemia, which suggests a protective effect of these cytokines, partly through the control of type II interferon production. The development of anemia requires the expression of Fcγ receptors (FcγR) I, III, and IV. Whereas LDV infection decreases FcγR III expression, it enhances FcγR I and IV expression in wild-type animals. The LDV-associated increase in the expression of FcγR I and IV is largely reduced in type I interferon receptor-deficient mice, through both type II interferon-dependent and -independent mechanisms. Thus, the regulation of the expression of FcγR I and IV, but not III, by interferons may partly explain the exacerbating effect of LDV infection on anemia that results from the enhanced phagocytosis of IgG autoantibody-opsonized erythrocytes. |
| first_indexed | 2024-03-10T08:43:30Z |
| format | Article |
| id | doaj.art-05d1f73350e14162a0a908ea3ebb3380 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T08:43:30Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-05d1f73350e14162a0a908ea3ebb33802023-11-22T08:04:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012216902710.3390/ijms22169027Involvement of Virus-Induced Interferon Production in IgG Autoantibody-Mediated AnemiaSarah Legrain0Dan Su1Mélanie Gaignage2Cor Breukel3Jill Claassens4Conny Brouwers5Margot M. Linssen6Shozo Izui7J. Sjef Verbeek8Jean-Paul Coutelier9Unit of Experimental Medicine, de Duve Institute, Université Catholique de Louvain, 1200 Bruxelles, BelgiumUnit of Experimental Medicine, de Duve Institute, Université Catholique de Louvain, 1200 Bruxelles, BelgiumUnit of Experimental Medicine, de Duve Institute, Université Catholique de Louvain, 1200 Bruxelles, BelgiumDepartment of Human Genetics, Leiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Human Genetics, Leiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Human Genetics, Leiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Human Genetics, Leiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Pathology and Immunology, Centre Médical Universitaire, University of Geneva, 4 1211 Geneva, SwitzerlandDepartment of Human Genetics, Leiden University Medical Center, 2300 RC Leiden, The NetherlandsUnit of Experimental Medicine, de Duve Institute, Université Catholique de Louvain, 1200 Bruxelles, BelgiumInfection with viruses, such as the lactate dehydrogenase-elevating virus (LDV), is known to trigger the onset of autoimmune anemia through the enhancement of the phagocytosis of autoantibody-opsonized erythrocytes by activated macrophages. Type I interferon receptor-deficient mice show enhanced anemia, which suggests a protective effect of these cytokines, partly through the control of type II interferon production. The development of anemia requires the expression of Fcγ receptors (FcγR) I, III, and IV. Whereas LDV infection decreases FcγR III expression, it enhances FcγR I and IV expression in wild-type animals. The LDV-associated increase in the expression of FcγR I and IV is largely reduced in type I interferon receptor-deficient mice, through both type II interferon-dependent and -independent mechanisms. Thus, the regulation of the expression of FcγR I and IV, but not III, by interferons may partly explain the exacerbating effect of LDV infection on anemia that results from the enhanced phagocytosis of IgG autoantibody-opsonized erythrocytes.https://www.mdpi.com/1422-0067/22/16/9027Fc receptorslactate dehydrogenase-elevating virusautoimmune anemiainterferon |
| spellingShingle | Sarah Legrain Dan Su Mélanie Gaignage Cor Breukel Jill Claassens Conny Brouwers Margot M. Linssen Shozo Izui J. Sjef Verbeek Jean-Paul Coutelier Involvement of Virus-Induced Interferon Production in IgG Autoantibody-Mediated Anemia International Journal of Molecular Sciences Fc receptors lactate dehydrogenase-elevating virus autoimmune anemia interferon |
| title | Involvement of Virus-Induced Interferon Production in IgG Autoantibody-Mediated Anemia |
| title_full | Involvement of Virus-Induced Interferon Production in IgG Autoantibody-Mediated Anemia |
| title_fullStr | Involvement of Virus-Induced Interferon Production in IgG Autoantibody-Mediated Anemia |
| title_full_unstemmed | Involvement of Virus-Induced Interferon Production in IgG Autoantibody-Mediated Anemia |
| title_short | Involvement of Virus-Induced Interferon Production in IgG Autoantibody-Mediated Anemia |
| title_sort | involvement of virus induced interferon production in igg autoantibody mediated anemia |
| topic | Fc receptors lactate dehydrogenase-elevating virus autoimmune anemia interferon |
| url | https://www.mdpi.com/1422-0067/22/16/9027 |
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