Genetic analyses of DNA repair pathway associated genes implicate new candidate cancer predisposing genes in ancestrally defined ovarian cancer cases

Genetic analyses of DNA repair pathway associated genes implicate new candidate cancer predisposing genes in ancestrally defined ovarian cancer cases

Not all familial ovarian cancer (OC) cases are explained by pathogenic germline variants in known risk genes. A candidate gene approach involving DNA repair pathway genes was applied to identify rare recurring pathogenic variants in familial OC cases not associated with known OC risk genes from a po...

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Bibliographic Details
Main Authors: Wejdan M. Alenezi, Caitlin T. Fierheller, Corinne Serruya, Timothée Revil, Kathleen K. Oros, Deepak N. Subramanian, Jeffrey Bruce, Dan Spiegelman, Trevor Pugh, Ian G. Campbell, Anne-Marie Mes-Masson, Diane Provencher, William D. Foulkes, Zaki El Haffaf, Guy Rouleau, Luigi Bouchard, Celia M. T. Greenwood, Jiannis Ragoussis, Patricia N. Tonin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Oncology
Subjects:
germline variants
familial ovarian cancer
cancer predisposing genes
whole exome sequencing
DNA repair pathways
Genetic drift
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1111191/full

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