Gradual compaction of the nascent peptide during cotranslational folding on the ribosome

Gradual compaction of the nascent peptide during cotranslational folding on the ribosome

Nascent polypeptides begin to fold in the constrained space of the ribosomal peptide exit tunnel. Here we use force-profile analysis (FPA) and photo-induced energy-transfer fluorescence correlation spectroscopy (PET-FCS) to show how a small α-helical domain, the N-terminal domain of HemK, folds cotr...

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Bibliographic Details
Main Authors: Marija Liutkute, Manisankar Maiti, Ekaterina Samatova, Jörg Enderlein, Marina V Rodnina
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
cotranslational folding
nascent chain dynamics
PET-FCS
HemK
ribosome
Online Access:https://elifesciences.org/articles/60895

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