Protective Effect of the α7 Nicotinic Receptor Agonist PNU-282987 on Dopaminergic Neurons Against 6-Hydroxydopamine, Regulating Anti-neuroinflammatory and the Immune Balance Pathways in Rat

Protective Effect of the α7 Nicotinic Receptor Agonist PNU-282987 on Dopaminergic Neurons Against 6-Hydroxydopamine, Regulating Anti-neuroinflammatory and the Immune Balance Pathways in Rat

Neuroinflammation and inner immune dysfunction are increasingly accepted as important components of the etiopathogenesis of Parkinson’s disease (PD). According to emerging evidence, a7 nicotinic acetylcholine receptor (α7nAChR), a ligand-gated ion channel, plays an important role in inflammatory rea...

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Bibliographic Details
Main Authors: Ying Jiang, Huizi Ma, Xuemei Wang, Zhan Wang, Yaqin Yang, Longling Li, Tao Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
α7 nicotinic acetylcholine receptors
PNU-282987
Treg
immune balance
Parkinson’s disease
rat
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2020.606927/full

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