Taking control: reorganization of the host cytoskeleton by Chlamydia [version 1; referees: 5 approved]
Both actin and microtubules are major cytoskeletal elements in eukaryotic cells that participate in many cellular processes, including cell division and motility, vesicle and organelle movement, and the maintenance of cell shape. Inside its host cell, the human pathogen Chlamydia trachomatis manipul...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2017-11-01
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| Series: | F1000Research |
| Subjects: | |
| Online Access: | https://f1000research.com/articles/6-2058/v1 |
| _version_ | 1819011695610167296 |
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| author | Jordan Wesolowski Fabienne Paumet |
| author_facet | Jordan Wesolowski Fabienne Paumet |
| author_sort | Jordan Wesolowski |
| collection | DOAJ |
| description | Both actin and microtubules are major cytoskeletal elements in eukaryotic cells that participate in many cellular processes, including cell division and motility, vesicle and organelle movement, and the maintenance of cell shape. Inside its host cell, the human pathogen Chlamydia trachomatis manipulates the cytoskeleton to promote its survival and enhance its pathogenicity. In particular, Chlamydia induces the drastic rearrangement of both actin and microtubules, which is vital for its entry, inclusion structure and development, and host cell exit. As significant progress in Chlamydia genetics has greatly enhanced our understanding of how this pathogen co-opts the host cytoskeleton, we will discuss the machinery used by Chlamydia to coordinate the reorganization of actin and microtubules. |
| first_indexed | 2024-12-21T01:32:15Z |
| format | Article |
| id | doaj.art-05d46bae32804eba86052aaab01d844e |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-21T01:32:15Z |
| publishDate | 2017-11-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-05d46bae32804eba86052aaab01d844e2022-12-21T19:20:19ZengF1000 Research LtdF1000Research2046-14022017-11-01610.12688/f1000research.12316.113333Taking control: reorganization of the host cytoskeleton by Chlamydia [version 1; referees: 5 approved]Jordan Wesolowski0Fabienne Paumet1Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA, 19107, USADepartment of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA, 19107, USABoth actin and microtubules are major cytoskeletal elements in eukaryotic cells that participate in many cellular processes, including cell division and motility, vesicle and organelle movement, and the maintenance of cell shape. Inside its host cell, the human pathogen Chlamydia trachomatis manipulates the cytoskeleton to promote its survival and enhance its pathogenicity. In particular, Chlamydia induces the drastic rearrangement of both actin and microtubules, which is vital for its entry, inclusion structure and development, and host cell exit. As significant progress in Chlamydia genetics has greatly enhanced our understanding of how this pathogen co-opts the host cytoskeleton, we will discuss the machinery used by Chlamydia to coordinate the reorganization of actin and microtubules.https://f1000research.com/articles/6-2058/v1Cellular Microbiology & PathogenesisCytoskeletonMedical MicrobiologyMembranes & SortingMicrobial Evolution & GenomicsMicrobial Physiology & Metabolism |
| spellingShingle | Jordan Wesolowski Fabienne Paumet Taking control: reorganization of the host cytoskeleton by Chlamydia [version 1; referees: 5 approved] F1000Research Cellular Microbiology & Pathogenesis Cytoskeleton Medical Microbiology Membranes & Sorting Microbial Evolution & Genomics Microbial Physiology & Metabolism |
| title | Taking control: reorganization of the host cytoskeleton by Chlamydia [version 1; referees: 5 approved] |
| title_full | Taking control: reorganization of the host cytoskeleton by Chlamydia [version 1; referees: 5 approved] |
| title_fullStr | Taking control: reorganization of the host cytoskeleton by Chlamydia [version 1; referees: 5 approved] |
| title_full_unstemmed | Taking control: reorganization of the host cytoskeleton by Chlamydia [version 1; referees: 5 approved] |
| title_short | Taking control: reorganization of the host cytoskeleton by Chlamydia [version 1; referees: 5 approved] |
| title_sort | taking control reorganization of the host cytoskeleton by chlamydia version 1 referees 5 approved |
| topic | Cellular Microbiology & Pathogenesis Cytoskeleton Medical Microbiology Membranes & Sorting Microbial Evolution & Genomics Microbial Physiology & Metabolism |
| url | https://f1000research.com/articles/6-2058/v1 |
| work_keys_str_mv | AT jordanwesolowski takingcontrolreorganizationofthehostcytoskeletonbychlamydiaversion1referees5approved AT fabiennepaumet takingcontrolreorganizationofthehostcytoskeletonbychlamydiaversion1referees5approved |