The Pathogenic Role of PI3K/AKT Pathway in Cancer Onset and Drug Resistance: An Updated Review

The Pathogenic Role of PI3K/AKT Pathway in Cancer Onset and Drug Resistance: An Updated Review

The PI3K/AKT pathway is one of the most frequently over-activated intracellular pathways in several human cancers. This pathway, acting on different downstream target proteins, contributes to the carcinogenesis, proliferation, invasion, and metastasis of tumour cells. A multi-level impairment, invol...

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Bibliographic Details
Main Authors: Federica Rascio, Federica Spadaccino, Maria Teresa Rocchetti, Giuseppe Castellano, Giovanni Stallone, Giuseppe Stefano Netti, Elena Ranieri
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
mTOR
Akt/PI3K pathway
tumour
drug resistance
regulatory mechanism
miRNA
Online Access:https://www.mdpi.com/2072-6694/13/16/3949

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