A novel digitonin/graphene oxide/iron oxide nanocomposite: synthesis, physiochemical characterization and antioxidant activity
Abstract In this work, iron oxide (Fe3O4) magnetic nanoparticles (MNPs) and graphene oxide (GO) nanosheets were prepared via the co-precipitation technique and the Modified Hummer method. Fe3O4 MNPs and GO nanosheets were combined to prepare Fe3O4/GO nanocomposite and subsequently conjugated with Di...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2024-01-01
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| Series: | Discover Nano |
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| Online Access: | https://doi.org/10.1186/s11671-024-03960-7 |
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| author | Bashar Aljawrneh Khaled Shawakfeh Borhan Aldeen Albiss Abdelelah Alshanableh Mahmoud A. Al-Qudah Tariq T. Bataineh Lona Shawakfeh |
| author_facet | Bashar Aljawrneh Khaled Shawakfeh Borhan Aldeen Albiss Abdelelah Alshanableh Mahmoud A. Al-Qudah Tariq T. Bataineh Lona Shawakfeh |
| author_sort | Bashar Aljawrneh |
| collection | DOAJ |
| description | Abstract In this work, iron oxide (Fe3O4) magnetic nanoparticles (MNPs) and graphene oxide (GO) nanosheets were prepared via the co-precipitation technique and the Modified Hummer method. Fe3O4 MNPs and GO nanosheets were combined to prepare Fe3O4/GO nanocomposite and subsequently conjugated with Digitonin (DIG) in order to obtain a dual-targeted delivery system based on DIG/Fe3O4/GO nanocomposite. SEM images reveal the presence of Fe3O4 MNPs at a scale of 100 nm, exhibiting dispersion between the GO nanosheets. Aggregation of the DIG/Fe3O4/GO nanocomposite was observed at various size scales. The XRD structural analysis confirms the crystal structure of the prepared samples. The Fe3O4 MNPs demonstrated the main XRD-diffracted peaks. Also, GO nanosheets exhibit crystalline characteristics on the (001) and (002) planes. The predominant peaks observed in the DIG/GO/Fe3O4 nanocomposite are attributed to the crystal phases of Fe3O4 MNPs. The FT-IR vibrational modes observed in the GO/DIG/Fe3O4 nanocomposite indicate the presence of crosslinking between GO nanosheet layers and the Fe3O4 MNPs. The antioxidant activity of the prepared samples was measured and the DIG/GO/Fe3O4 nanocomposite demonstrated a significantly high antioxidant activity in both 2-diphenyl-1-picrylhydrazyl (DPPH·) and 2,2-azino-bis-3-ethylbenzthiazoline-6-sulfonic acid (ABTS·+) tests. |
| first_indexed | 2024-03-07T15:26:23Z |
| format | Article |
| id | doaj.art-05d847ff7cb34f3496e41cb85dd0769b |
| institution | Directory Open Access Journal |
| issn | 2731-9229 |
| language | English |
| last_indexed | 2024-03-07T15:26:23Z |
| publishDate | 2024-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Nano |
| spelling | doaj.art-05d847ff7cb34f3496e41cb85dd0769b2024-03-05T16:39:11ZengSpringerDiscover Nano2731-92292024-01-0119111210.1186/s11671-024-03960-7A novel digitonin/graphene oxide/iron oxide nanocomposite: synthesis, physiochemical characterization and antioxidant activityBashar Aljawrneh0Khaled Shawakfeh1Borhan Aldeen Albiss2Abdelelah Alshanableh3Mahmoud A. Al-Qudah4Tariq T. Bataineh5Lona Shawakfeh6Department of Physics, Al-Zaytoonah University of JordanDepartment of Chemistry, Jordan University of Science and TechnologyNanotechnology Institute, Jordan University of Science and TechnologyNanotechnology Institute, Jordan University of Science and TechnologyDepartment of Chemistry, Faculty of Science, Yarmouk UniversityDepartment of Chemistry, Faculty of Science, Yarmouk UniversityThe Joint School of Nanoscience and Nanoengineering, University of North Carolina at GreensboroAbstract In this work, iron oxide (Fe3O4) magnetic nanoparticles (MNPs) and graphene oxide (GO) nanosheets were prepared via the co-precipitation technique and the Modified Hummer method. Fe3O4 MNPs and GO nanosheets were combined to prepare Fe3O4/GO nanocomposite and subsequently conjugated with Digitonin (DIG) in order to obtain a dual-targeted delivery system based on DIG/Fe3O4/GO nanocomposite. SEM images reveal the presence of Fe3O4 MNPs at a scale of 100 nm, exhibiting dispersion between the GO nanosheets. Aggregation of the DIG/Fe3O4/GO nanocomposite was observed at various size scales. The XRD structural analysis confirms the crystal structure of the prepared samples. The Fe3O4 MNPs demonstrated the main XRD-diffracted peaks. Also, GO nanosheets exhibit crystalline characteristics on the (001) and (002) planes. The predominant peaks observed in the DIG/GO/Fe3O4 nanocomposite are attributed to the crystal phases of Fe3O4 MNPs. The FT-IR vibrational modes observed in the GO/DIG/Fe3O4 nanocomposite indicate the presence of crosslinking between GO nanosheet layers and the Fe3O4 MNPs. The antioxidant activity of the prepared samples was measured and the DIG/GO/Fe3O4 nanocomposite demonstrated a significantly high antioxidant activity in both 2-diphenyl-1-picrylhydrazyl (DPPH·) and 2,2-azino-bis-3-ethylbenzthiazoline-6-sulfonic acid (ABTS·+) tests.https://doi.org/10.1186/s11671-024-03960-7Graphene oxideIron magnetite nanoparticlesDigitoninFunctionalizationAntioxidant activity |
| spellingShingle | Bashar Aljawrneh Khaled Shawakfeh Borhan Aldeen Albiss Abdelelah Alshanableh Mahmoud A. Al-Qudah Tariq T. Bataineh Lona Shawakfeh A novel digitonin/graphene oxide/iron oxide nanocomposite: synthesis, physiochemical characterization and antioxidant activity Discover Nano Graphene oxide Iron magnetite nanoparticles Digitonin Functionalization Antioxidant activity |
| title | A novel digitonin/graphene oxide/iron oxide nanocomposite: synthesis, physiochemical characterization and antioxidant activity |
| title_full | A novel digitonin/graphene oxide/iron oxide nanocomposite: synthesis, physiochemical characterization and antioxidant activity |
| title_fullStr | A novel digitonin/graphene oxide/iron oxide nanocomposite: synthesis, physiochemical characterization and antioxidant activity |
| title_full_unstemmed | A novel digitonin/graphene oxide/iron oxide nanocomposite: synthesis, physiochemical characterization and antioxidant activity |
| title_short | A novel digitonin/graphene oxide/iron oxide nanocomposite: synthesis, physiochemical characterization and antioxidant activity |
| title_sort | novel digitonin graphene oxide iron oxide nanocomposite synthesis physiochemical characterization and antioxidant activity |
| topic | Graphene oxide Iron magnetite nanoparticles Digitonin Functionalization Antioxidant activity |
| url | https://doi.org/10.1186/s11671-024-03960-7 |
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