Comparing the Effects of Melatonin and Zolpidem on Sleep Quality, Depression, and Anxiety in Patients With Colorectal Cancer Undergoing Chemotherapy
Introduction: Patients with cancer may have many complications involving their psychosomatic systems, such as sleep disturbance, depression, and anxiety. Thus, many research studies were conducted to reduce these complications. Zolpidem, as a short-term non-benzodiazepine treatment of insomnia, and...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2021-01-01
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| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.iums.ac.ir/article-1-1476-en.html |
| _version_ | 1797281100473565184 |
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| author | Maryam Shahrokhi Padideh Ghaeli Pantea Arya Alia Shakiba Afsaneh Noormandi Mehdi Soleimani Mohsen Esfandbod |
| author_facet | Maryam Shahrokhi Padideh Ghaeli Pantea Arya Alia Shakiba Afsaneh Noormandi Mehdi Soleimani Mohsen Esfandbod |
| author_sort | Maryam Shahrokhi |
| collection | DOAJ |
| description | Introduction: Patients with cancer may have many complications involving their psychosomatic systems, such as sleep disturbance, depression, and anxiety. Thus, many research studies were conducted to reduce these complications. Zolpidem, as a short-term non-benzodiazepine treatment of insomnia, and melatonin as a chronobiological function-regulatory hormone, are commonly used for improving sleep quality. This randomized clinical trial aims to compare the effects of zolpidem and melatonin on sleep quality, depression, and anxiety in patients with colorectal cancer.
Methods: In this single-blinded trial, 90 patients with colorectal cancer undergoing chemotherapy who had obtained a score of 5 or higher on the Pittsburgh Sleep Quality Index (PSQI) were randomly divided into two groups (n=45). One group was treated with 10 mg zolpidem at bedtime, and the other group received 6 mg melatonin at bedtime for 30 days. PSQI on weeks 0, 4, 8, Groningen sleep quality scale, Hamilton rating scale for depression, and Hamilton anxiety rating scale questionnaires were performed to assess patients on weeks 0, 4, and 8. The outcome was then analyzed, and P≤0.05 was considered statistically significant.
Results: Both zolpidem and melatonin had significant impacts on sleep quality in week 4 (P<0.05). After stopping the treatments, the conditions were noticeably reversed on week 8 (P<0.05). Zolpidem and melatonin were relatively similar in affecting sleep duration, latency, efficiency, and disturbance. None of the two study medications had any considerable influence on anxiety and depression.
Conclusion: Melatonin and zolpidem are promising agents for treating sleep complications and, to some extent, depression, and anxiety in cancer patients, according to the present study. However, further clinical trials are recommended to confirm the results of this study. |
| first_indexed | 2024-03-07T16:52:42Z |
| format | Article |
| id | doaj.art-05d8963e948f4ff2b2b3d8093a91a4a0 |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T16:52:42Z |
| publishDate | 2021-01-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-05d8963e948f4ff2b2b3d8093a91a4a02024-03-03T04:39:33ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422021-01-01121105114Comparing the Effects of Melatonin and Zolpidem on Sleep Quality, Depression, and Anxiety in Patients With Colorectal Cancer Undergoing ChemotherapyMaryam Shahrokhi0Padideh Ghaeli1Pantea Arya2Alia Shakiba3Afsaneh Noormandi4Mehdi Soleimani5Mohsen Esfandbod6 Department of Clinical Pharmacy, Faculty of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran. Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Department of Psychiatry, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. Psychiatry and Psychoogy Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Department of Psychiatry, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. Hematology-Oncology and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran. Introduction: Patients with cancer may have many complications involving their psychosomatic systems, such as sleep disturbance, depression, and anxiety. Thus, many research studies were conducted to reduce these complications. Zolpidem, as a short-term non-benzodiazepine treatment of insomnia, and melatonin as a chronobiological function-regulatory hormone, are commonly used for improving sleep quality. This randomized clinical trial aims to compare the effects of zolpidem and melatonin on sleep quality, depression, and anxiety in patients with colorectal cancer. Methods: In this single-blinded trial, 90 patients with colorectal cancer undergoing chemotherapy who had obtained a score of 5 or higher on the Pittsburgh Sleep Quality Index (PSQI) were randomly divided into two groups (n=45). One group was treated with 10 mg zolpidem at bedtime, and the other group received 6 mg melatonin at bedtime for 30 days. PSQI on weeks 0, 4, 8, Groningen sleep quality scale, Hamilton rating scale for depression, and Hamilton anxiety rating scale questionnaires were performed to assess patients on weeks 0, 4, and 8. The outcome was then analyzed, and P≤0.05 was considered statistically significant. Results: Both zolpidem and melatonin had significant impacts on sleep quality in week 4 (P<0.05). After stopping the treatments, the conditions were noticeably reversed on week 8 (P<0.05). Zolpidem and melatonin were relatively similar in affecting sleep duration, latency, efficiency, and disturbance. None of the two study medications had any considerable influence on anxiety and depression. Conclusion: Melatonin and zolpidem are promising agents for treating sleep complications and, to some extent, depression, and anxiety in cancer patients, according to the present study. However, further clinical trials are recommended to confirm the results of this study.http://bcn.iums.ac.ir/article-1-1476-en.htmlneoplasmssleep initiation and maintenance disordersdepressionanxietyzolpidemmelatonin |
| spellingShingle | Maryam Shahrokhi Padideh Ghaeli Pantea Arya Alia Shakiba Afsaneh Noormandi Mehdi Soleimani Mohsen Esfandbod Comparing the Effects of Melatonin and Zolpidem on Sleep Quality, Depression, and Anxiety in Patients With Colorectal Cancer Undergoing Chemotherapy Basic and Clinical Neuroscience neoplasms sleep initiation and maintenance disorders depression anxiety zolpidem melatonin |
| title | Comparing the Effects of Melatonin and Zolpidem on Sleep Quality, Depression, and Anxiety in Patients With Colorectal Cancer Undergoing Chemotherapy |
| title_full | Comparing the Effects of Melatonin and Zolpidem on Sleep Quality, Depression, and Anxiety in Patients With Colorectal Cancer Undergoing Chemotherapy |
| title_fullStr | Comparing the Effects of Melatonin and Zolpidem on Sleep Quality, Depression, and Anxiety in Patients With Colorectal Cancer Undergoing Chemotherapy |
| title_full_unstemmed | Comparing the Effects of Melatonin and Zolpidem on Sleep Quality, Depression, and Anxiety in Patients With Colorectal Cancer Undergoing Chemotherapy |
| title_short | Comparing the Effects of Melatonin and Zolpidem on Sleep Quality, Depression, and Anxiety in Patients With Colorectal Cancer Undergoing Chemotherapy |
| title_sort | comparing the effects of melatonin and zolpidem on sleep quality depression and anxiety in patients with colorectal cancer undergoing chemotherapy |
| topic | neoplasms sleep initiation and maintenance disorders depression anxiety zolpidem melatonin |
| url | http://bcn.iums.ac.ir/article-1-1476-en.html |
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