Potentially Inappropriate Use of Opioids in the Management of Migraine in Colombia
Research objective: To identify the frequency of opioid use in a group of patients diagnosed with migraine in Colombia. Methods: Study of a retrospective cohort of patients with a diagnosis of migraine and a first prescription of antimigraine drugs from emergency services and a priority outpatient c...
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| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/9/2385 |
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| author | Manuel E. Machado-Duque Maria Fernanda Echeverry-Gutiérrez Andrés Gaviria-Mendoza Luis F. Valladales-Restrepo Jorge E. Machado-Alba |
| author_facet | Manuel E. Machado-Duque Maria Fernanda Echeverry-Gutiérrez Andrés Gaviria-Mendoza Luis F. Valladales-Restrepo Jorge E. Machado-Alba |
| author_sort | Manuel E. Machado-Duque |
| collection | DOAJ |
| description | Research objective: To identify the frequency of opioid use in a group of patients diagnosed with migraine in Colombia. Methods: Study of a retrospective cohort of patients with a diagnosis of migraine and a first prescription of antimigraine drugs from emergency services and a priority outpatient clinic. Sociodemographic, clinical, and pharmacological variables were identified; a 12-month follow-up was carried out to identify the use of a new opioid. Results: A total of 6309 patients with a diagnosis of migraine were identified, with a mean age of 35.5 ± 12.3 years, of which 81.3% were women. Nonsteroidal anti-inflammatory drugs (51.1%) were the most frequently prescribed medications, followed by ergotamine + caffeine (31.3%), acetaminophen (15.05%), and acetaminophen + codeine (14.4%). At the time of the index, 1300 (20.6%) patients received some opioid. During the follow-up, a total of 1437 (22.8%) patients received a new opioid, of which 31.8% belonged to the group that received an initial opioid and 20.4% to the group that did not receive one, which was statistically significant (OR:1.81; 95%CI:1.58–2.07; <i>p</i> < 0.001). Conclusions: The frequent use of opioids in the management of migraines is potentially inappropriate and can lead to problems of tolerance, abuse and dependence. This combined with the low prescription of triptans, offers an opportunity for improvements in medical practice. |
| first_indexed | 2024-03-10T22:59:56Z |
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| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T22:59:56Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-05d8c043d96e48319250548944c805242023-11-19T09:40:34ZengMDPI AGBiomedicines2227-90592023-08-01119238510.3390/biomedicines11092385Potentially Inappropriate Use of Opioids in the Management of Migraine in ColombiaManuel E. Machado-Duque0Maria Fernanda Echeverry-Gutiérrez1Andrés Gaviria-Mendoza2Luis F. Valladales-Restrepo3Jorge E. Machado-Alba4Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A, Pereira 660003, ColombiaGrupo de Investigación Biomedicina, Facultad de Medicina, Fundación Universitaria Autónoma de Las Américas, Pereira 660003, ColombiaGrupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A, Pereira 660003, ColombiaGrupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A, Pereira 660003, ColombiaGrupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A, Pereira 660003, ColombiaResearch objective: To identify the frequency of opioid use in a group of patients diagnosed with migraine in Colombia. Methods: Study of a retrospective cohort of patients with a diagnosis of migraine and a first prescription of antimigraine drugs from emergency services and a priority outpatient clinic. Sociodemographic, clinical, and pharmacological variables were identified; a 12-month follow-up was carried out to identify the use of a new opioid. Results: A total of 6309 patients with a diagnosis of migraine were identified, with a mean age of 35.5 ± 12.3 years, of which 81.3% were women. Nonsteroidal anti-inflammatory drugs (51.1%) were the most frequently prescribed medications, followed by ergotamine + caffeine (31.3%), acetaminophen (15.05%), and acetaminophen + codeine (14.4%). At the time of the index, 1300 (20.6%) patients received some opioid. During the follow-up, a total of 1437 (22.8%) patients received a new opioid, of which 31.8% belonged to the group that received an initial opioid and 20.4% to the group that did not receive one, which was statistically significant (OR:1.81; 95%CI:1.58–2.07; <i>p</i> < 0.001). Conclusions: The frequent use of opioids in the management of migraines is potentially inappropriate and can lead to problems of tolerance, abuse and dependence. This combined with the low prescription of triptans, offers an opportunity for improvements in medical practice.https://www.mdpi.com/2227-9059/11/9/2385opioid analgesicsmigrainedrug-related side effectsadverse reactionsheadachepharmacoepidemiology |
| spellingShingle | Manuel E. Machado-Duque Maria Fernanda Echeverry-Gutiérrez Andrés Gaviria-Mendoza Luis F. Valladales-Restrepo Jorge E. Machado-Alba Potentially Inappropriate Use of Opioids in the Management of Migraine in Colombia Biomedicines opioid analgesics migraine drug-related side effects adverse reactions headache pharmacoepidemiology |
| title | Potentially Inappropriate Use of Opioids in the Management of Migraine in Colombia |
| title_full | Potentially Inappropriate Use of Opioids in the Management of Migraine in Colombia |
| title_fullStr | Potentially Inappropriate Use of Opioids in the Management of Migraine in Colombia |
| title_full_unstemmed | Potentially Inappropriate Use of Opioids in the Management of Migraine in Colombia |
| title_short | Potentially Inappropriate Use of Opioids in the Management of Migraine in Colombia |
| title_sort | potentially inappropriate use of opioids in the management of migraine in colombia |
| topic | opioid analgesics migraine drug-related side effects adverse reactions headache pharmacoepidemiology |
| url | https://www.mdpi.com/2227-9059/11/9/2385 |
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