D-Lactate: Implications for Gastrointestinal Diseases
D-lactate is produced in very low amounts in human tissues. However, certain bacteria in the human intestine produce D-lactate. In some gastrointestinal diseases, increased bacterial D-lactate production and uptake from the gut into the bloodstream take place. In its extreme, excessive accumulation...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/10/6/945 |
| _version_ | 1797595436008079360 |
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| author | Barblin Remund Bahtiyar Yilmaz Christiane Sokollik |
| author_facet | Barblin Remund Bahtiyar Yilmaz Christiane Sokollik |
| author_sort | Barblin Remund |
| collection | DOAJ |
| description | D-lactate is produced in very low amounts in human tissues. However, certain bacteria in the human intestine produce D-lactate. In some gastrointestinal diseases, increased bacterial D-lactate production and uptake from the gut into the bloodstream take place. In its extreme, excessive accumulation of D-lactate in humans can lead to potentially life-threatening D-lactic acidosis. This metabolic phenomenon is well described in pediatric patients with short bowel syndrome. Less is known about a subclinical rise in D-lactate. We discuss in this review the pathophysiology of D-lactate in the human body. We cover D-lactic acidosis in patients with short bowel syndrome as well as subclinical elevations of D-lactate in other diseases affecting the gastrointestinal tract. Furthermore, we argue for the potential of D-lactate as a marker of intestinal barrier integrity in the context of dysbiosis. Subsequently, we conclude that there is a research need to establish D-lactate as a minimally invasive biomarker in gastrointestinal diseases. |
| first_indexed | 2024-03-11T02:37:28Z |
| format | Article |
| id | doaj.art-05da29ab56e34f5dafa21150cad9be1d |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-11T02:37:28Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-05da29ab56e34f5dafa21150cad9be1d2023-11-18T09:49:25ZengMDPI AGChildren2227-90672023-05-0110694510.3390/children10060945D-Lactate: Implications for Gastrointestinal DiseasesBarblin Remund0Bahtiyar Yilmaz1Christiane Sokollik2Division of Paediatric Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, SwitzerlandDepartment of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, 3010 Bern, SwitzerlandDivision of Paediatric Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, SwitzerlandD-lactate is produced in very low amounts in human tissues. However, certain bacteria in the human intestine produce D-lactate. In some gastrointestinal diseases, increased bacterial D-lactate production and uptake from the gut into the bloodstream take place. In its extreme, excessive accumulation of D-lactate in humans can lead to potentially life-threatening D-lactic acidosis. This metabolic phenomenon is well described in pediatric patients with short bowel syndrome. Less is known about a subclinical rise in D-lactate. We discuss in this review the pathophysiology of D-lactate in the human body. We cover D-lactic acidosis in patients with short bowel syndrome as well as subclinical elevations of D-lactate in other diseases affecting the gastrointestinal tract. Furthermore, we argue for the potential of D-lactate as a marker of intestinal barrier integrity in the context of dysbiosis. Subsequently, we conclude that there is a research need to establish D-lactate as a minimally invasive biomarker in gastrointestinal diseases.https://www.mdpi.com/2227-9067/10/6/945inflammatory bowel diseaseshort bowel syndromebiomarkerintestinal permeabilitydysbiosis |
| spellingShingle | Barblin Remund Bahtiyar Yilmaz Christiane Sokollik D-Lactate: Implications for Gastrointestinal Diseases Children inflammatory bowel disease short bowel syndrome biomarker intestinal permeability dysbiosis |
| title | D-Lactate: Implications for Gastrointestinal Diseases |
| title_full | D-Lactate: Implications for Gastrointestinal Diseases |
| title_fullStr | D-Lactate: Implications for Gastrointestinal Diseases |
| title_full_unstemmed | D-Lactate: Implications for Gastrointestinal Diseases |
| title_short | D-Lactate: Implications for Gastrointestinal Diseases |
| title_sort | d lactate implications for gastrointestinal diseases |
| topic | inflammatory bowel disease short bowel syndrome biomarker intestinal permeability dysbiosis |
| url | https://www.mdpi.com/2227-9067/10/6/945 |
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