Platelets involved tumor cell EMT during circulation: communications and interventions
Abstract Distant spreading of metastatic tumor cells is still the leading cause of tumor death. Metastatic spreading is a complex process, in which epithelial-mesenchymal transition (EMT) is the primary and key event to promote it. Presently, extensive reviews have given insights on the occurrence o...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-022-00887-3 |
| _version_ | 1811240315439284224 |
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| author | Xiaoying Wang Songyan Zhao Zhaoxia Wang Tao Gao |
| author_facet | Xiaoying Wang Songyan Zhao Zhaoxia Wang Tao Gao |
| author_sort | Xiaoying Wang |
| collection | DOAJ |
| description | Abstract Distant spreading of metastatic tumor cells is still the leading cause of tumor death. Metastatic spreading is a complex process, in which epithelial-mesenchymal transition (EMT) is the primary and key event to promote it. Presently, extensive reviews have given insights on the occurrence of EMT at the primary tumor site that depends on invasive properties of tumor cells and the tumor-associated microenvironment. However, essential roles of circulation environment involved in tumor cell EMT is not well summarized. As a main constituent of the blood, platelet is increasingly found to work as an important activator to induce EMT. Therefore, this review aims to emphasize the novel role of platelet in EMT through signal communications between platelets and circulation tumor cells, and illustrate potent interventions aiming at their communications. It may give a complementary view of EMT in addition to the tissue microenvironment, help for better understand the hematogenous metastasis, and also illustrate theoretical and practical basis for the targeted inhibition. Video abstract |
| first_indexed | 2024-04-12T13:18:01Z |
| format | Article |
| id | doaj.art-05da804f39ab4c2c8b62cf53242eca8c |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-04-12T13:18:01Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-05da804f39ab4c2c8b62cf53242eca8c2022-12-22T03:31:36ZengBMCCell Communication and Signaling1478-811X2022-06-0120111210.1186/s12964-022-00887-3Platelets involved tumor cell EMT during circulation: communications and interventionsXiaoying Wang0Songyan Zhao1Zhaoxia Wang2Tao Gao3Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal UniversityJiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal UniversityDepartment of Oncology, The Second Affiliated Hospital of Nanjing Medical UniversityJiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal UniversityAbstract Distant spreading of metastatic tumor cells is still the leading cause of tumor death. Metastatic spreading is a complex process, in which epithelial-mesenchymal transition (EMT) is the primary and key event to promote it. Presently, extensive reviews have given insights on the occurrence of EMT at the primary tumor site that depends on invasive properties of tumor cells and the tumor-associated microenvironment. However, essential roles of circulation environment involved in tumor cell EMT is not well summarized. As a main constituent of the blood, platelet is increasingly found to work as an important activator to induce EMT. Therefore, this review aims to emphasize the novel role of platelet in EMT through signal communications between platelets and circulation tumor cells, and illustrate potent interventions aiming at their communications. It may give a complementary view of EMT in addition to the tissue microenvironment, help for better understand the hematogenous metastasis, and also illustrate theoretical and practical basis for the targeted inhibition. Video abstracthttps://doi.org/10.1186/s12964-022-00887-3PlateletCirculation tumor cellEMTHematogenous metastasisSignal communications |
| spellingShingle | Xiaoying Wang Songyan Zhao Zhaoxia Wang Tao Gao Platelets involved tumor cell EMT during circulation: communications and interventions Cell Communication and Signaling Platelet Circulation tumor cell EMT Hematogenous metastasis Signal communications |
| title | Platelets involved tumor cell EMT during circulation: communications and interventions |
| title_full | Platelets involved tumor cell EMT during circulation: communications and interventions |
| title_fullStr | Platelets involved tumor cell EMT during circulation: communications and interventions |
| title_full_unstemmed | Platelets involved tumor cell EMT during circulation: communications and interventions |
| title_short | Platelets involved tumor cell EMT during circulation: communications and interventions |
| title_sort | platelets involved tumor cell emt during circulation communications and interventions |
| topic | Platelet Circulation tumor cell EMT Hematogenous metastasis Signal communications |
| url | https://doi.org/10.1186/s12964-022-00887-3 |
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