Analysis of Multi-Part Phenotypic Changes in Skin to Characterize the Trajectory of Skin Aging in Chinese Women
Yan Zhang,1,* Xiaoyu Liu,2,3,* Jingpu Wang,3 Le Du,3 Yanyun Ma,4– 6 Wei Liu,7 Rui Ye,3 Yali Yang,1,* Hui Xu1 1Department of Dermatology, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Dep...
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| Format: | Article |
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Dove Medical Press
2022-04-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
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| Online Access: | https://www.dovepress.com/analysis-of-multi-part-phenotypic-changes-in-skin-to-characterize-the--peer-reviewed-fulltext-article-CCID |
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| author | Zhang Y Liu X Wang J Du L Ma Y Liu W Ye R Yang Y Xu H |
| author_facet | Zhang Y Liu X Wang J Du L Ma Y Liu W Ye R Yang Y Xu H |
| author_sort | Zhang Y |
| collection | DOAJ |
| description | Yan Zhang,1,* Xiaoyu Liu,2,3,* Jingpu Wang,3 Le Du,3 Yanyun Ma,4– 6 Wei Liu,7 Rui Ye,3 Yali Yang,1,* Hui Xu1 1Department of Dermatology, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Molecular Diagnostics & Endocrinology, The Core Laboratory in Medical Center of Clinical Research, State Key Laboratory of Medical Genomics, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 3Inertiabiotech Co., LTD, Shanghai, People’s Republic of China; 4Human Phenome Institute, Fudan University, Shanghai, People’s Republic of China; 5State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, People’s Republic of China; 6Institute for Six-Sector Economy, Fudan University, Shanghai, People’s Republic of China; 7Department of Dermatology, The Medical Center of Air Force PLA, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hui Xu, Department of Dermatology, Shanghai Ninth People’s Hospital, No. 639, Manufacturing Bureau Road, Shanghai, People’s Republic of China, Email XUH1786@sh9hospital.org.cn Rui Ye, Inertiabiotech Co., LTD, Shanghai, People’s Republic of China, Email rye@inertiabiotech.comPurpose: As the human body’s largest organ exposed to the external environment, the skin suffers from internal and external aging factors, leading to wrinkles, loss of elasticity, sagging, and rough appearance. However, little is known of the characteristics of skin aging of different body parts in Chinese women. Here, we study the signs of extrinsic skin aging in different body parts to identify the knowledge map of manifestations of aging in Chinese women.Patients and Methods: Wrinkle and texture phenotypes and collagen samples from the face, neck, hands, and arms of 326 Chinese women were collected. The correlations between phenotypes and ages and the differences in phenotypes by age were evaluated.Results: The wrinkle and texture phenotypes around the eyes and mouth and of the hands were strongly correlated with age. Ages 32 and 58 showed the largest number of differentially changed aging phenotypes. The number of aging phenotypes increased sharply between the ages of 24 and 30, suggesting that the skin was undergoing rapid aging. Eye aging was the most rapidly changing phenotype between 19 and 30 years old. Wrinkles at the corner of the eyes showed a significant difference in the older group, suggesting an early onset and long-term effects.Conclusion: This is the first study to be performed on the characteristics of skin aging among Chinese women that takes account of multiple areas of the body. It was found that 24 years old was the time point at which the skin begins to age in Chinese women. This provides important clues for aging-related research and personalized skin care.Keywords: aging, Chinese women, phenotypes, skin, wrinkles |
| first_indexed | 2024-04-13T03:17:03Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-04-13T03:17:03Z |
| publishDate | 2022-04-01 |
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| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-05daa291fe254f71aa6c517808b1cf512022-12-22T03:04:53ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152022-04-01Volume 1563164274456Analysis of Multi-Part Phenotypic Changes in Skin to Characterize the Trajectory of Skin Aging in Chinese WomenZhang YLiu XWang JDu LMa YLiu WYe RYang YXu HYan Zhang,1,* Xiaoyu Liu,2,3,* Jingpu Wang,3 Le Du,3 Yanyun Ma,4– 6 Wei Liu,7 Rui Ye,3 Yali Yang,1,* Hui Xu1 1Department of Dermatology, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Molecular Diagnostics & Endocrinology, The Core Laboratory in Medical Center of Clinical Research, State Key Laboratory of Medical Genomics, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 3Inertiabiotech Co., LTD, Shanghai, People’s Republic of China; 4Human Phenome Institute, Fudan University, Shanghai, People’s Republic of China; 5State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, People’s Republic of China; 6Institute for Six-Sector Economy, Fudan University, Shanghai, People’s Republic of China; 7Department of Dermatology, The Medical Center of Air Force PLA, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hui Xu, Department of Dermatology, Shanghai Ninth People’s Hospital, No. 639, Manufacturing Bureau Road, Shanghai, People’s Republic of China, Email XUH1786@sh9hospital.org.cn Rui Ye, Inertiabiotech Co., LTD, Shanghai, People’s Republic of China, Email rye@inertiabiotech.comPurpose: As the human body’s largest organ exposed to the external environment, the skin suffers from internal and external aging factors, leading to wrinkles, loss of elasticity, sagging, and rough appearance. However, little is known of the characteristics of skin aging of different body parts in Chinese women. Here, we study the signs of extrinsic skin aging in different body parts to identify the knowledge map of manifestations of aging in Chinese women.Patients and Methods: Wrinkle and texture phenotypes and collagen samples from the face, neck, hands, and arms of 326 Chinese women were collected. The correlations between phenotypes and ages and the differences in phenotypes by age were evaluated.Results: The wrinkle and texture phenotypes around the eyes and mouth and of the hands were strongly correlated with age. Ages 32 and 58 showed the largest number of differentially changed aging phenotypes. The number of aging phenotypes increased sharply between the ages of 24 and 30, suggesting that the skin was undergoing rapid aging. Eye aging was the most rapidly changing phenotype between 19 and 30 years old. Wrinkles at the corner of the eyes showed a significant difference in the older group, suggesting an early onset and long-term effects.Conclusion: This is the first study to be performed on the characteristics of skin aging among Chinese women that takes account of multiple areas of the body. It was found that 24 years old was the time point at which the skin begins to age in Chinese women. This provides important clues for aging-related research and personalized skin care.Keywords: aging, Chinese women, phenotypes, skin, wrinkleshttps://www.dovepress.com/analysis-of-multi-part-phenotypic-changes-in-skin-to-characterize-the--peer-reviewed-fulltext-article-CCIDagingchinese womenphenotypesskinwrinkles |
| spellingShingle | Zhang Y Liu X Wang J Du L Ma Y Liu W Ye R Yang Y Xu H Analysis of Multi-Part Phenotypic Changes in Skin to Characterize the Trajectory of Skin Aging in Chinese Women Clinical, Cosmetic and Investigational Dermatology aging chinese women phenotypes skin wrinkles |
| title | Analysis of Multi-Part Phenotypic Changes in Skin to Characterize the Trajectory of Skin Aging in Chinese Women |
| title_full | Analysis of Multi-Part Phenotypic Changes in Skin to Characterize the Trajectory of Skin Aging in Chinese Women |
| title_fullStr | Analysis of Multi-Part Phenotypic Changes in Skin to Characterize the Trajectory of Skin Aging in Chinese Women |
| title_full_unstemmed | Analysis of Multi-Part Phenotypic Changes in Skin to Characterize the Trajectory of Skin Aging in Chinese Women |
| title_short | Analysis of Multi-Part Phenotypic Changes in Skin to Characterize the Trajectory of Skin Aging in Chinese Women |
| title_sort | analysis of multi part phenotypic changes in skin to characterize the trajectory of skin aging in chinese women |
| topic | aging chinese women phenotypes skin wrinkles |
| url | https://www.dovepress.com/analysis-of-multi-part-phenotypic-changes-in-skin-to-characterize-the--peer-reviewed-fulltext-article-CCID |
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