Solithromycin inhibits IL-13-induced goblet cell hyperplasia and MUC5AC, CLCA1, and ANO1 in human bronchial epithelial cells

Solithromycin inhibits IL-13-induced goblet cell hyperplasia and MUC5AC, CLCA1, and ANO1 in human bronchial epithelial cells

Solithromycin is a novel fluoroketolide antibiotic belonging to the class of macrolide antibiotics. Activation of the interleukin (IL)-13 receptor leads to STAT6 activation and subsequent induction of SAM pointed domain containing ETS transcription factor (SPDEF), chloride channel accessory 1 (CLCA1...

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Bibliographic Details
Main Authors: Yasuhiro Kimura, Masahiro Shinoda, Masaharu Shinkai, Takeshi Kaneko
Format: Article
Language:English
Published: PeerJ Inc. 2023-01-01
Series:PeerJ
Subjects:
Solithromycin
Goblet cell
SAM pointed domain containing ETS transcription factor
Chloride channel accessory 1
Mucin
MUC5AC
Online Access:https://peerj.com/articles/14695.pdf

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