Quorum sensing in <em>Acinetobacter</em>: with special emphasis on antibiotic resistance, biofilm formation and quorum quenching
<em>Acinetobacter</em> is an important nosocomial, opportunistic human pathogen that is gradually gaining more attention as a major health threat worldwide. Quorum sensing (QS) is a cell-cell communication system in which specific signaling molecules called autoinducers accumulate in the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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AIMS Press
2016-02-01
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| Series: | AIMS Microbiology |
| Subjects: | |
| Online Access: | http://www.aimspress.com/microbiology/article/655/fulltext.html |
| _version_ | 1819054120414216192 |
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| author | Bindu Subhadra Man Hwan Oh Chul Hee Choi |
| author_facet | Bindu Subhadra Man Hwan Oh Chul Hee Choi |
| author_sort | Bindu Subhadra |
| collection | DOAJ |
| description | <em>Acinetobacter</em> is an important nosocomial, opportunistic human pathogen that is gradually gaining more attention as a major health threat worldwide. Quorum sensing (QS) is a cell-cell communication system in which specific signaling molecules called autoinducers accumulate in the medium as the population density grows and control various physiological processes including production of virulence factors, biofilm and development of antibiotic resistance. The complex QS machinery in <em>Acinetobacter</em> is mediated by a two-component system which is homologous to the typical LuxI/LuxR system found in Gram-negative bacteria. This cell signaling system comprises of a sensor protein that functions as autoinducer synthase and a receptor protein which binds to the signal molecules, acyl homoserine lactones inducing a cascade of reactions. Lately, disruption of QS has emerged as an anti-virulence strategy with great therapeutic potential. Here, we depict the current understanding of the existing QS network in <em>Acinetobacter</em> and describe important anti-virulent strategies developed in order to effectively tackle this pathogen. In addition, the prospects of quorum quenching to control <em>Acinetobacter</em> infections is also been discussed. |
| first_indexed | 2024-12-21T12:46:34Z |
| format | Article |
| id | doaj.art-05dd77824be74bccbe2fa485def7b126 |
| institution | Directory Open Access Journal |
| issn | 2471-1888 |
| language | English |
| last_indexed | 2024-12-21T12:46:34Z |
| publishDate | 2016-02-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Microbiology |
| spelling | doaj.art-05dd77824be74bccbe2fa485def7b1262022-12-21T19:03:38ZengAIMS PressAIMS Microbiology2471-18882016-02-0121274110.3934/microbiol.2016.1.27microbiol-02-00027Quorum sensing in <em>Acinetobacter</em>: with special emphasis on antibiotic resistance, biofilm formation and quorum quenchingBindu Subhadra0Man Hwan Oh1Chul Hee Choi2Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Republic of KoreaDepartment of Nanobiomedical Science, Dankook University, Cheonan, Republic of KoreaDepartment of Microbiology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea<em>Acinetobacter</em> is an important nosocomial, opportunistic human pathogen that is gradually gaining more attention as a major health threat worldwide. Quorum sensing (QS) is a cell-cell communication system in which specific signaling molecules called autoinducers accumulate in the medium as the population density grows and control various physiological processes including production of virulence factors, biofilm and development of antibiotic resistance. The complex QS machinery in <em>Acinetobacter</em> is mediated by a two-component system which is homologous to the typical LuxI/LuxR system found in Gram-negative bacteria. This cell signaling system comprises of a sensor protein that functions as autoinducer synthase and a receptor protein which binds to the signal molecules, acyl homoserine lactones inducing a cascade of reactions. Lately, disruption of QS has emerged as an anti-virulence strategy with great therapeutic potential. Here, we depict the current understanding of the existing QS network in <em>Acinetobacter</em> and describe important anti-virulent strategies developed in order to effectively tackle this pathogen. In addition, the prospects of quorum quenching to control <em>Acinetobacter</em> infections is also been discussed.http://www.aimspress.com/microbiology/article/655/fulltext.htmlquorum sensing<em>Acinetobacter</em>quorum quenchingbiofilmAntibiotic resistancevirulence factorsacyl homoserine lactones<em> anoR</em><em>anoI</em> |
| spellingShingle | Bindu Subhadra Man Hwan Oh Chul Hee Choi Quorum sensing in <em>Acinetobacter</em>: with special emphasis on antibiotic resistance, biofilm formation and quorum quenching AIMS Microbiology quorum sensing <em>Acinetobacter</em> quorum quenching biofilm Antibiotic resistance virulence factors acyl homoserine lactones <em> anoR</em> <em>anoI</em> |
| title | Quorum sensing in <em>Acinetobacter</em>: with special emphasis on antibiotic resistance, biofilm formation and quorum quenching |
| title_full | Quorum sensing in <em>Acinetobacter</em>: with special emphasis on antibiotic resistance, biofilm formation and quorum quenching |
| title_fullStr | Quorum sensing in <em>Acinetobacter</em>: with special emphasis on antibiotic resistance, biofilm formation and quorum quenching |
| title_full_unstemmed | Quorum sensing in <em>Acinetobacter</em>: with special emphasis on antibiotic resistance, biofilm formation and quorum quenching |
| title_short | Quorum sensing in <em>Acinetobacter</em>: with special emphasis on antibiotic resistance, biofilm formation and quorum quenching |
| title_sort | quorum sensing in em acinetobacter em with special emphasis on antibiotic resistance biofilm formation and quorum quenching |
| topic | quorum sensing <em>Acinetobacter</em> quorum quenching biofilm Antibiotic resistance virulence factors acyl homoserine lactones <em> anoR</em> <em>anoI</em> |
| url | http://www.aimspress.com/microbiology/article/655/fulltext.html |
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