A randomized controlled trial of folic acid intervention in pregnancy highlights a putative methylation-regulated control element at ZFP57

A randomized controlled trial of folic acid intervention in pregnancy highlights a putative methylation-regulated control element at ZFP57

Abstract Background Maternal blood folate concentrations during pregnancy have been previously linked with DNA methylation patterns, but this has been done predominantly through observational studies. We showed recently in an epigenetic analysis of the first randomized controlled trial (RCT) of foli...

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Bibliographic Details
Main Authors: Rachelle E. Irwin, Sara-Jayne Thursby, Miroslava Ondičová, Kristina Pentieva, Helene McNulty, Rebecca C. Richmond, Aoife Caffrey, Diane J. Lees-Murdock, Marian McLaughlin, Tony Cassidy, Matthew Suderman, Caroline L. Relton, Colum P. Walsh
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Clinical Epigenetics
Subjects:
Folic acid
DNA methylation
Cord blood
Offspring
Imprinting
ZFP57
Online Access:http://link.springer.com/article/10.1186/s13148-019-0618-0

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