Luminescent AIE Dots for Anticancer Photodynamic Therapy
Photodynamic therapy (PDT) is an emerging effective strategy for cancer treatment. Compared with conventional cancer therapies, such as surgery, chemotherapy, and radiotherapy, PDT has shown great promise as a next-generation cancer therapeutic strategy owing to its many advantages such as non-invas...
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| Format: | Article |
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2021.672917/full |
| _version_ | 1819322979684712448 |
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| author | Zhenyan He Sidan Tian Yuting Gao Fanling Meng Liang Luo Liang Luo |
| author_facet | Zhenyan He Sidan Tian Yuting Gao Fanling Meng Liang Luo Liang Luo |
| author_sort | Zhenyan He |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) is an emerging effective strategy for cancer treatment. Compared with conventional cancer therapies, such as surgery, chemotherapy, and radiotherapy, PDT has shown great promise as a next-generation cancer therapeutic strategy owing to its many advantages such as non-invasiveness, negligible observed drug resistance, localized treatment, and fewer side effects. One of the key elements in photodynamic therapy is the photosensitizer (PS) which converts photons into active cytotoxic species, namely, reactive oxygen species (ROS). An ideal PS for photodynamic therapy requires the efficient generation of ROS, high stability against photo bleaching, and robust performance in different environments and concentrations. PSs with aggregation-induced emission (AIE) characteristics have drawn significant attention, in that they can overcome the aggregation- caused quenching effect that is commonly seen in the case of fluorescence dyes and provide excellent performance at high concentrations or in their condensed state. Moreover, organic nanomaterials with AIE characteristics, or AIE dots, have played an increasingly significant role in assisting PDT based on its excellent ROS generation efficiency and simultaneous imaging feature. This review summarizes the recent advances on the molecular design of AIE PSs and AIE dots-based probes, as well as their emerging applications for enhanced anticancer PDT theranostics. |
| first_indexed | 2024-12-24T11:59:58Z |
| format | Article |
| id | doaj.art-05df6e3584bf4606a22c8fb59d569267 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-24T11:59:58Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-05df6e3584bf4606a22c8fb59d5692672022-12-21T16:56:20ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462021-05-01910.3389/fchem.2021.672917672917Luminescent AIE Dots for Anticancer Photodynamic TherapyZhenyan He0Sidan Tian1Yuting Gao2Fanling Meng3Liang Luo4Liang Luo5National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaNational Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaNational Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaNational Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaNational Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, ChinaPhotodynamic therapy (PDT) is an emerging effective strategy for cancer treatment. Compared with conventional cancer therapies, such as surgery, chemotherapy, and radiotherapy, PDT has shown great promise as a next-generation cancer therapeutic strategy owing to its many advantages such as non-invasiveness, negligible observed drug resistance, localized treatment, and fewer side effects. One of the key elements in photodynamic therapy is the photosensitizer (PS) which converts photons into active cytotoxic species, namely, reactive oxygen species (ROS). An ideal PS for photodynamic therapy requires the efficient generation of ROS, high stability against photo bleaching, and robust performance in different environments and concentrations. PSs with aggregation-induced emission (AIE) characteristics have drawn significant attention, in that they can overcome the aggregation- caused quenching effect that is commonly seen in the case of fluorescence dyes and provide excellent performance at high concentrations or in their condensed state. Moreover, organic nanomaterials with AIE characteristics, or AIE dots, have played an increasingly significant role in assisting PDT based on its excellent ROS generation efficiency and simultaneous imaging feature. This review summarizes the recent advances on the molecular design of AIE PSs and AIE dots-based probes, as well as their emerging applications for enhanced anticancer PDT theranostics.https://www.frontiersin.org/articles/10.3389/fchem.2021.672917/fullphotodynamic therapyphotosensitizersaggregation-induced emissionAIE dotstheranostics |
| spellingShingle | Zhenyan He Sidan Tian Yuting Gao Fanling Meng Liang Luo Liang Luo Luminescent AIE Dots for Anticancer Photodynamic Therapy Frontiers in Chemistry photodynamic therapy photosensitizers aggregation-induced emission AIE dots theranostics |
| title | Luminescent AIE Dots for Anticancer Photodynamic Therapy |
| title_full | Luminescent AIE Dots for Anticancer Photodynamic Therapy |
| title_fullStr | Luminescent AIE Dots for Anticancer Photodynamic Therapy |
| title_full_unstemmed | Luminescent AIE Dots for Anticancer Photodynamic Therapy |
| title_short | Luminescent AIE Dots for Anticancer Photodynamic Therapy |
| title_sort | luminescent aie dots for anticancer photodynamic therapy |
| topic | photodynamic therapy photosensitizers aggregation-induced emission AIE dots theranostics |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2021.672917/full |
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