A photoactive injectable antibacterial hydrogel to support chemo-immunotherapeutic effect of antigenic cell membrane and sorafenib by near-infrared light mediated tumor ablation
Intravenously administered nanocarriers suffer from off-target distribution, pre-targeting drug leakage, and rapid clearance, limiting their efficiency in tumor eradication. To bypass these challenges, an injectable hydrogel with time- and temperature-dependent viscosity enhancement behavior and sel...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-04-01
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| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006423000698 |
| _version_ | 1797854308352393216 |
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| author | Samin Abbaszadeh Mohammad Reza Eskandari Vahideh Nosrati-Siahmazgi Kiyan Musaie Soraya Mehrabi Ruikang Tang Mohammad Reza Jafari Bo Xiao Vahid Hosseinpour Sarmadi Fakhri Haghi Bo Zhi Chen Xin Dong Guo Hélder A. Santos Mohammad-Ali Shahbazi |
| author_facet | Samin Abbaszadeh Mohammad Reza Eskandari Vahideh Nosrati-Siahmazgi Kiyan Musaie Soraya Mehrabi Ruikang Tang Mohammad Reza Jafari Bo Xiao Vahid Hosseinpour Sarmadi Fakhri Haghi Bo Zhi Chen Xin Dong Guo Hélder A. Santos Mohammad-Ali Shahbazi |
| author_sort | Samin Abbaszadeh |
| collection | DOAJ |
| description | Intravenously administered nanocarriers suffer from off-target distribution, pre-targeting drug leakage, and rapid clearance, limiting their efficiency in tumor eradication. To bypass these challenges, an injectable hydrogel with time- and temperature-dependent viscosity enhancement behavior and self-healing property are reported to assist in the retention of the hydrogel in the tumor site after injection. The cancer cell membrane (CCM) and sorafenib are embedded into the hydrogel to elicit local tumor-specific immune responses and induce cancer cell apoptosis, respectively. In addition, hyaluronic acid (HA) coated Bi2S3 nanorods (BiH) are incorporated within the hydrogel to afford prolonged multi-cycle local photothermal therapy (PTT) due to the reduced diffusion of the nanorods to the surrounding tissues as a result of HA affinity toward cancer cells. The results show the promotion of immunostimulatory responses by both CCM and PTT through the release of inflammatory cytokines from immune cells, which allows localized and complete ablation of the breast tumor in an animal model by a single injection of the hydrogel. Moreover, the BiH renders strong antibacterial activity to the hydrogel, which is crucial for the clinical translation of injectable hydrogels as it minimizes the risk of infection in the post-cancer lesion formed by PTT-mediated cancer therapy. |
| first_indexed | 2024-04-09T20:03:51Z |
| format | Article |
| id | doaj.art-05e0ca72db16447da8ce9cad400216e2 |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-04-09T20:03:51Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-05e0ca72db16447da8ce9cad400216e22023-04-02T06:15:06ZengElsevierMaterials Today Bio2590-00642023-04-0119100609A photoactive injectable antibacterial hydrogel to support chemo-immunotherapeutic effect of antigenic cell membrane and sorafenib by near-infrared light mediated tumor ablationSamin Abbaszadeh0Mohammad Reza Eskandari1Vahideh Nosrati-Siahmazgi2Kiyan Musaie3Soraya Mehrabi4Ruikang Tang5Mohammad Reza Jafari6Bo Xiao7Vahid Hosseinpour Sarmadi8Fakhri Haghi9Bo Zhi Chen10Xin Dong Guo11Hélder A. Santos12Mohammad-Ali Shahbazi13Department of Pharmacology, School of Medicine, Zanjan University of Medical Sciences, 45139-56111, Zanjan, IranDepartment of Pharmacology and Toxicology, School of Pharmacy, Zanjan University of Medical Science, 45139-56184, Zanjan, IranDepartment of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Science, 45139-56184, Zanjan, IranDepartment of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Science, 45139-56184, Zanjan, IranDepartment of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, 14496-14535, Tehran, IranCenter for Biomaterials and Biopathways, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027, ChinaDepartment of Pharmacology, School of Medicine, Zanjan University of Medical Sciences, 45139-56111, Zanjan, IranState Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, 400715, ChinaCellular and Molecular Research Center, Iran University of Medical Sciences, 14496-14535, Tehran, IranDepartment of Microbiology and Immunology, School of Medicine, Zanjan University of Medical Sciences, 45139-56111, Zanjan, IranBeijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, ChinaBeijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, China; Corresponding author.Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, Netherlands; W.J. Kolff Institute for Biomedical Engineering and Materials Science, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, the Netherlands; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014, Helsinki, Finland; Corresponding author. Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, Netherlands.Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, Netherlands; W.J. Kolff Institute for Biomedical Engineering and Materials Science, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, the Netherlands; Corresponding author. Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, Netherlands.Intravenously administered nanocarriers suffer from off-target distribution, pre-targeting drug leakage, and rapid clearance, limiting their efficiency in tumor eradication. To bypass these challenges, an injectable hydrogel with time- and temperature-dependent viscosity enhancement behavior and self-healing property are reported to assist in the retention of the hydrogel in the tumor site after injection. The cancer cell membrane (CCM) and sorafenib are embedded into the hydrogel to elicit local tumor-specific immune responses and induce cancer cell apoptosis, respectively. In addition, hyaluronic acid (HA) coated Bi2S3 nanorods (BiH) are incorporated within the hydrogel to afford prolonged multi-cycle local photothermal therapy (PTT) due to the reduced diffusion of the nanorods to the surrounding tissues as a result of HA affinity toward cancer cells. The results show the promotion of immunostimulatory responses by both CCM and PTT through the release of inflammatory cytokines from immune cells, which allows localized and complete ablation of the breast tumor in an animal model by a single injection of the hydrogel. Moreover, the BiH renders strong antibacterial activity to the hydrogel, which is crucial for the clinical translation of injectable hydrogels as it minimizes the risk of infection in the post-cancer lesion formed by PTT-mediated cancer therapy.http://www.sciencedirect.com/science/article/pii/S2590006423000698Combination therapyPhotothermal therapyChemotherapyImmunotherapyBreast cancer |
| spellingShingle | Samin Abbaszadeh Mohammad Reza Eskandari Vahideh Nosrati-Siahmazgi Kiyan Musaie Soraya Mehrabi Ruikang Tang Mohammad Reza Jafari Bo Xiao Vahid Hosseinpour Sarmadi Fakhri Haghi Bo Zhi Chen Xin Dong Guo Hélder A. Santos Mohammad-Ali Shahbazi A photoactive injectable antibacterial hydrogel to support chemo-immunotherapeutic effect of antigenic cell membrane and sorafenib by near-infrared light mediated tumor ablation Materials Today Bio Combination therapy Photothermal therapy Chemotherapy Immunotherapy Breast cancer |
| title | A photoactive injectable antibacterial hydrogel to support chemo-immunotherapeutic effect of antigenic cell membrane and sorafenib by near-infrared light mediated tumor ablation |
| title_full | A photoactive injectable antibacterial hydrogel to support chemo-immunotherapeutic effect of antigenic cell membrane and sorafenib by near-infrared light mediated tumor ablation |
| title_fullStr | A photoactive injectable antibacterial hydrogel to support chemo-immunotherapeutic effect of antigenic cell membrane and sorafenib by near-infrared light mediated tumor ablation |
| title_full_unstemmed | A photoactive injectable antibacterial hydrogel to support chemo-immunotherapeutic effect of antigenic cell membrane and sorafenib by near-infrared light mediated tumor ablation |
| title_short | A photoactive injectable antibacterial hydrogel to support chemo-immunotherapeutic effect of antigenic cell membrane and sorafenib by near-infrared light mediated tumor ablation |
| title_sort | photoactive injectable antibacterial hydrogel to support chemo immunotherapeutic effect of antigenic cell membrane and sorafenib by near infrared light mediated tumor ablation |
| topic | Combination therapy Photothermal therapy Chemotherapy Immunotherapy Breast cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2590006423000698 |
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