Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding.

Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding.

The Ebola virus (EBOV) envelope glycoprotein (GP) is a membrane fusion machine required for virus entry into cells. Following endocytosis of EBOV, the GP1 domain is cleaved by cellular cathepsins in acidic endosomes, removing the glycan cap and exposing a binding site for the Niemann-Pick C1 (NPC1)...

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Bibliographic Details
Main Authors:	Dibyendu Kumar Das, Uriel Bulow, William E Diehl, Natasha D Durham, Fernando Senjobe, Kartik Chandran, Jeremy Luban, James B Munro
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2020-02-01
Series:	PLoS Biology
Online Access:	https://doi.org/10.1371/journal.pbio.3000626

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