Effects of two different types of luteal support on pregnancy outcomes following antagonist fresh embryo transfer: a retrospective study
Abstract Background Only a small number of studies have reported the use of progesterone vaginal gel in combination with dydrogesterone as part of the antagonist protocol for fresh embryo transfer. Therefore, this study aimed to compare the effects of two types of luteal support on pregnancy outcome...
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Pregnancy and Childbirth |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12884-023-05570-0 |
| _version_ | 1797831792748658688 |
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| author | Minji De Lixue Chen Lin Zeng Yang Wang Rui Yang Rong Li Hongbin Chi |
| author_facet | Minji De Lixue Chen Lin Zeng Yang Wang Rui Yang Rong Li Hongbin Chi |
| author_sort | Minji De |
| collection | DOAJ |
| description | Abstract Background Only a small number of studies have reported the use of progesterone vaginal gel in combination with dydrogesterone as part of the antagonist protocol for fresh embryo transfer. Therefore, this study aimed to compare the effects of two types of luteal support on pregnancy outcomes following the antagonist protocol for fresh embryo transfer. Methods We performed a retrospective analysis of clinical data from infertile patients who underwent fresh embryo transfer via the antagonist protocol (2785 cycles) between February and July 2019 and between February and July 2021 at the Peking University Third Hospital Reproductive Medicine Centre. According to the luteal support received, the cycle groups were divided into the progesterone vaginal gel group (single medication or VP group; 1170 cycles) and the progesterone vaginal gel plus dydrogesterone group (combination medication or DYD + VP group; 1615 cycles). After propensity score matching, the clinical pregnancy, ongoing pregnancy, early miscarriage, and ectopic pregnancy rates were compared between the two groups. Results In total, 1057 pairs of cycles were successfully matched via propensity scores. The clinical and ongoing pregnancy rates in the combination medication group were significantly higher than those in the single medication group (P < 0.05), whereas no significant differences were noted in the early miscarriage and ectopic pregnancy rates between the two groups (both P > 0.05). Conclusions Combined luteal support after the antagonist protocol is preferred for patients undergoing fresh cycle embryo transfer. |
| first_indexed | 2024-04-09T13:58:29Z |
| format | Article |
| id | doaj.art-05e1cb2d69674e8dbdb10e18e67c34cc |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-04-09T13:58:29Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-05e1cb2d69674e8dbdb10e18e67c34cc2023-05-07T11:26:44ZengBMCBMC Pregnancy and Childbirth1471-23932023-05-012311710.1186/s12884-023-05570-0Effects of two different types of luteal support on pregnancy outcomes following antagonist fresh embryo transfer: a retrospective studyMinji De0Lixue Chen1Lin Zeng2Yang Wang3Rui Yang4Rong Li5Hongbin Chi6Reproductive Medicine Center, Peking University Third HospitalReproductive Medicine Center, Peking University Third HospitalReproductive Medicine Center, Peking University Third HospitalReproductive Medicine Center, Peking University Third HospitalReproductive Medicine Center, Peking University Third HospitalReproductive Medicine Center, Peking University Third HospitalReproductive Medicine Center, Peking University Third HospitalAbstract Background Only a small number of studies have reported the use of progesterone vaginal gel in combination with dydrogesterone as part of the antagonist protocol for fresh embryo transfer. Therefore, this study aimed to compare the effects of two types of luteal support on pregnancy outcomes following the antagonist protocol for fresh embryo transfer. Methods We performed a retrospective analysis of clinical data from infertile patients who underwent fresh embryo transfer via the antagonist protocol (2785 cycles) between February and July 2019 and between February and July 2021 at the Peking University Third Hospital Reproductive Medicine Centre. According to the luteal support received, the cycle groups were divided into the progesterone vaginal gel group (single medication or VP group; 1170 cycles) and the progesterone vaginal gel plus dydrogesterone group (combination medication or DYD + VP group; 1615 cycles). After propensity score matching, the clinical pregnancy, ongoing pregnancy, early miscarriage, and ectopic pregnancy rates were compared between the two groups. Results In total, 1057 pairs of cycles were successfully matched via propensity scores. The clinical and ongoing pregnancy rates in the combination medication group were significantly higher than those in the single medication group (P < 0.05), whereas no significant differences were noted in the early miscarriage and ectopic pregnancy rates between the two groups (both P > 0.05). Conclusions Combined luteal support after the antagonist protocol is preferred for patients undergoing fresh cycle embryo transfer.https://doi.org/10.1186/s12884-023-05570-0In vitro fertilization-embryo transferAntagonistsLuteal supportPregnancy outcomePropensity score matching |
| spellingShingle | Minji De Lixue Chen Lin Zeng Yang Wang Rui Yang Rong Li Hongbin Chi Effects of two different types of luteal support on pregnancy outcomes following antagonist fresh embryo transfer: a retrospective study BMC Pregnancy and Childbirth In vitro fertilization-embryo transfer Antagonists Luteal support Pregnancy outcome Propensity score matching |
| title | Effects of two different types of luteal support on pregnancy outcomes following antagonist fresh embryo transfer: a retrospective study |
| title_full | Effects of two different types of luteal support on pregnancy outcomes following antagonist fresh embryo transfer: a retrospective study |
| title_fullStr | Effects of two different types of luteal support on pregnancy outcomes following antagonist fresh embryo transfer: a retrospective study |
| title_full_unstemmed | Effects of two different types of luteal support on pregnancy outcomes following antagonist fresh embryo transfer: a retrospective study |
| title_short | Effects of two different types of luteal support on pregnancy outcomes following antagonist fresh embryo transfer: a retrospective study |
| title_sort | effects of two different types of luteal support on pregnancy outcomes following antagonist fresh embryo transfer a retrospective study |
| topic | In vitro fertilization-embryo transfer Antagonists Luteal support Pregnancy outcome Propensity score matching |
| url | https://doi.org/10.1186/s12884-023-05570-0 |
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