Identifying Potent Nonsense-Mediated mRNA Decay Inhibitors with a Novel Screening System

Identifying Potent Nonsense-Mediated mRNA Decay Inhibitors with a Novel Screening System

Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that degrades mRNAs carrying a premature termination codon. Its inhibition, alone or in combination with other approaches, could be exploited to develop therapies for genetic diseases caused by a nonsense mutation. This, however, requ...

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Bibliographic Details
Main Authors:	Julie Carrard, Fiona Ratajczak, Joséphine Elsens, Catherine Leroy, Rebekah Kong, Lucie Geoffroy, Arnaud Comte, Guy Fournet, Benoît Joseph, Xiubin Li, Sylvie Moebs-Sanchez, Fabrice Lejeune
Format:	Article
Language:	English
Published:	MDPI AG 2023-10-01
Series:	Biomedicines
Subjects:	nonsense mutation small molecules therapy nonsense-mediated mRNA decay genetic disease
Online Access:	https://www.mdpi.com/2227-9059/11/10/2801

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