APPLICATION OF HYDROPHYILIC INTERACTIONS LIQUID CHROMATOGRAPHY FOR ORGANIC NITRATE ANALYSIS
The possibility of the use of chromatographic columns with amino sorbents for the analysis of nitroglycerin and separation of isosorbide dinitrate and isomers of isosorbide mononitrate was investigated. As the mobile phase used a mixture of acetonitrile and water. Separation of analytes on amino col...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/296 |
| _version_ | 1797875003312570368 |
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| author | A. S. Osipov E. B. Nechaeva L. A. Truhacheva |
| author_facet | A. S. Osipov E. B. Nechaeva L. A. Truhacheva |
| author_sort | A. S. Osipov |
| collection | DOAJ |
| description | The possibility of the use of chromatographic columns with amino sorbents for the analysis of nitroglycerin and separation of isosorbide dinitrate and isomers of isosorbide mononitrate was investigated. As the mobile phase used a mixture of acetonitrile and water. Separation of analytes on amino columns in condition of the hydrophilic interaction liquid chromatography possible with acetonitrile content in the mobile phase, more 95%. Best separation isomers of isosorbide mononitrate on column Zorbax NH2, 150×4,6 mm was achieved with acetonitrile content in the mobile phase 99,8%. Separation of isosobide dinitrate and isosorbide mononitrates on columns with amino sorbents resulted in changing the sequence of elution of these compounds compared to reversed-phase chromatography. |
| first_indexed | 2024-04-10T01:40:54Z |
| format | Article |
| id | doaj.art-05e2ba6fba2e44029f1c9fa49d42482d |
| institution | Directory Open Access Journal |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| last_indexed | 2024-04-10T01:40:54Z |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj.art-05e2ba6fba2e44029f1c9fa49d42482d2023-03-13T09:13:57ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-0103108111296APPLICATION OF HYDROPHYILIC INTERACTIONS LIQUID CHROMATOGRAPHY FOR ORGANIC NITRATE ANALYSISA. S. Osipov0E. B. Nechaeva1L. A. Truhacheva2ФГБУ «Научный центр экспертизы средств медицинского применения» Министерства здравоохранения Российской ФедерацииФГБУ «Научный центр экспертизы средств медицинского применения» Министерства здравоохранения Российской ФедерацииФГБУ «Научный центр экспертизы средств медицинского применения» Министерства здравоохранения Российской ФедерацииThe possibility of the use of chromatographic columns with amino sorbents for the analysis of nitroglycerin and separation of isosorbide dinitrate and isomers of isosorbide mononitrate was investigated. As the mobile phase used a mixture of acetonitrile and water. Separation of analytes on amino columns in condition of the hydrophilic interaction liquid chromatography possible with acetonitrile content in the mobile phase, more 95%. Best separation isomers of isosorbide mononitrate on column Zorbax NH2, 150×4,6 mm was achieved with acetonitrile content in the mobile phase 99,8%. Separation of isosobide dinitrate and isosorbide mononitrates on columns with amino sorbents resulted in changing the sequence of elution of these compounds compared to reversed-phase chromatography.https://www.pharmjournal.ru/jour/article/view/296вэжхглицерина тринитрат (нитроглицерин)изосорбида динитратизосорбида мононитрат |
| spellingShingle | A. S. Osipov E. B. Nechaeva L. A. Truhacheva APPLICATION OF HYDROPHYILIC INTERACTIONS LIQUID CHROMATOGRAPHY FOR ORGANIC NITRATE ANALYSIS Разработка и регистрация лекарственных средств вэжх глицерина тринитрат (нитроглицерин) изосорбида динитрат изосорбида мононитрат |
| title | APPLICATION OF HYDROPHYILIC INTERACTIONS LIQUID CHROMATOGRAPHY FOR ORGANIC NITRATE ANALYSIS |
| title_full | APPLICATION OF HYDROPHYILIC INTERACTIONS LIQUID CHROMATOGRAPHY FOR ORGANIC NITRATE ANALYSIS |
| title_fullStr | APPLICATION OF HYDROPHYILIC INTERACTIONS LIQUID CHROMATOGRAPHY FOR ORGANIC NITRATE ANALYSIS |
| title_full_unstemmed | APPLICATION OF HYDROPHYILIC INTERACTIONS LIQUID CHROMATOGRAPHY FOR ORGANIC NITRATE ANALYSIS |
| title_short | APPLICATION OF HYDROPHYILIC INTERACTIONS LIQUID CHROMATOGRAPHY FOR ORGANIC NITRATE ANALYSIS |
| title_sort | application of hydrophyilic interactions liquid chromatography for organic nitrate analysis |
| topic | вэжх глицерина тринитрат (нитроглицерин) изосорбида динитрат изосорбида мононитрат |
| url | https://www.pharmjournal.ru/jour/article/view/296 |
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