Biosynthesis of S-adenosyl-methionine enhances aging-related defects in Drosophila oogenesis
Abstract Tissue aging is a major cause of aging-related disabilities and a shortened life span. Understanding how tissue aging progresses and identifying the factors underlying tissue aging are crucial; however, the mechanism of tissue aging is not fully understood. Here we show that the biosynthesi...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-09424-1 |
| _version_ | 1819061378278752256 |
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| author | Yoshiki Hayashi Soshiro Kashio Kazutoshi Murotomi Shinjiro Hino Woojin Kang Kenji Miyado Mitsuyoshi Nakao Masayuki Miura Satoru Kobayashi Masakazu Namihira |
| author_facet | Yoshiki Hayashi Soshiro Kashio Kazutoshi Murotomi Shinjiro Hino Woojin Kang Kenji Miyado Mitsuyoshi Nakao Masayuki Miura Satoru Kobayashi Masakazu Namihira |
| author_sort | Yoshiki Hayashi |
| collection | DOAJ |
| description | Abstract Tissue aging is a major cause of aging-related disabilities and a shortened life span. Understanding how tissue aging progresses and identifying the factors underlying tissue aging are crucial; however, the mechanism of tissue aging is not fully understood. Here we show that the biosynthesis of S-adenosyl-methionine (SAM), the major cellular donor of methyl group for methylation modifications, potently accelerates the aging-related defects during Drosophila oogenesis. An aging-related increase in the SAM-synthetase (Sam-S) levels in the germline leads to an increase in ovarian SAM levels. Sam-S-dependent biosynthesis of SAM controls aging-related defects in oogenesis through two mechanisms, decreasing the ability to maintain germline stem cells and accelerating the improper formation of egg chambers. Aging-related increases in SAM commonly occur in mouse reproductive tissue and the brain. Therefore, our results raise the possibility suggesting that SAM is the factor related to tissue aging beyond the species and tissues. |
| first_indexed | 2024-12-21T14:41:56Z |
| format | Article |
| id | doaj.art-05e309c3bbee4546af40f1bf690393d7 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-21T14:41:56Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-05e309c3bbee4546af40f1bf690393d72022-12-21T19:00:09ZengNature PortfolioScientific Reports2045-23222022-04-011211910.1038/s41598-022-09424-1Biosynthesis of S-adenosyl-methionine enhances aging-related defects in Drosophila oogenesisYoshiki Hayashi0Soshiro Kashio1Kazutoshi Murotomi2Shinjiro Hino3Woojin Kang4Kenji Miyado5Mitsuyoshi Nakao6Masayuki Miura7Satoru Kobayashi8Masakazu Namihira9Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of TsukubaDepartment of Genetics, Graduate School of Pharmaceutical Science, The University of TokyoBiomedical Research Institute, National Institute of Advanced Industrial Science and TechnologyInstitute of Molecular Embryology and Genetics, Kumamoto UniversityDepartment of Reproductive Biology, National Research Institute for Child Health and DevelopmentDepartment of Reproductive Biology, National Research Institute for Child Health and DevelopmentInstitute of Molecular Embryology and Genetics, Kumamoto UniversityDepartment of Genetics, Graduate School of Pharmaceutical Science, The University of TokyoLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of TsukubaBiomedical Research Institute, National Institute of Advanced Industrial Science and TechnologyAbstract Tissue aging is a major cause of aging-related disabilities and a shortened life span. Understanding how tissue aging progresses and identifying the factors underlying tissue aging are crucial; however, the mechanism of tissue aging is not fully understood. Here we show that the biosynthesis of S-adenosyl-methionine (SAM), the major cellular donor of methyl group for methylation modifications, potently accelerates the aging-related defects during Drosophila oogenesis. An aging-related increase in the SAM-synthetase (Sam-S) levels in the germline leads to an increase in ovarian SAM levels. Sam-S-dependent biosynthesis of SAM controls aging-related defects in oogenesis through two mechanisms, decreasing the ability to maintain germline stem cells and accelerating the improper formation of egg chambers. Aging-related increases in SAM commonly occur in mouse reproductive tissue and the brain. Therefore, our results raise the possibility suggesting that SAM is the factor related to tissue aging beyond the species and tissues.https://doi.org/10.1038/s41598-022-09424-1 |
| spellingShingle | Yoshiki Hayashi Soshiro Kashio Kazutoshi Murotomi Shinjiro Hino Woojin Kang Kenji Miyado Mitsuyoshi Nakao Masayuki Miura Satoru Kobayashi Masakazu Namihira Biosynthesis of S-adenosyl-methionine enhances aging-related defects in Drosophila oogenesis Scientific Reports |
| title | Biosynthesis of S-adenosyl-methionine enhances aging-related defects in Drosophila oogenesis |
| title_full | Biosynthesis of S-adenosyl-methionine enhances aging-related defects in Drosophila oogenesis |
| title_fullStr | Biosynthesis of S-adenosyl-methionine enhances aging-related defects in Drosophila oogenesis |
| title_full_unstemmed | Biosynthesis of S-adenosyl-methionine enhances aging-related defects in Drosophila oogenesis |
| title_short | Biosynthesis of S-adenosyl-methionine enhances aging-related defects in Drosophila oogenesis |
| title_sort | biosynthesis of s adenosyl methionine enhances aging related defects in drosophila oogenesis |
| url | https://doi.org/10.1038/s41598-022-09424-1 |
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