Normal weight obesity is associated with lower AFC and adverse IVF outcomes
BackgroundBody weight could be classified into underweight, normal weight and overweight according to percentage of body fat (%BF), and normal weight obesity (NWO) is defined as a normal BMI but a high %BF. While the impact of NWO in women fecundity remain unknow. Therefore, this study aimed to inve...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1332995/full |
| _version_ | 1797300263162216448 |
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| author | Yangcheng Yao Yangcheng Yao Wenjuan Liu Xiqian Zhang Nianjun Su Li Huang Yingqi Nong Xiaomin Xiao Fenghua Liu |
| author_facet | Yangcheng Yao Yangcheng Yao Wenjuan Liu Xiqian Zhang Nianjun Su Li Huang Yingqi Nong Xiaomin Xiao Fenghua Liu |
| author_sort | Yangcheng Yao |
| collection | DOAJ |
| description | BackgroundBody weight could be classified into underweight, normal weight and overweight according to percentage of body fat (%BF), and normal weight obesity (NWO) is defined as a normal BMI but a high %BF. While the impact of NWO in women fecundity remain unknow. Therefore, this study aimed to investigate the associations between %BF and reproductive outcomes among in vitro fertilization (IVF) women with normal BMI.MethodsA total of 469 women were included in this study and were classified into low %BF, normal %BF and high %BF according to previous study. Multivariate generalized regression models were employed to evaluate the associations of %BF with ovarian reserve parameters, IVF outcomes and early pregnancy outcomes. We further run sensitivity analyses by restricted the analysis to young women and those only with tubal factor, respectively.ResultsAbout 32.2% of normal BMI women were misclassified according %BF, with 16.4% of them were low %BF and 15.8% were high %BF. The high %BF group had significantly lower antral follicle count (AFC) than normal %BF groups, and the AFC showed a tendency of decrease as %BF increased. In sensitivity analysis in young women, high %BF group also had significantly lower number of good-quality embryos when compared to normal %BF groups. The results expanded to all IVF outcomes when analysis restricted to tubal factor women.ConclusionIn summary, misclassifications of body weight status based on BMI are common according to %BF, and NWO is associated with adverse reproductive outcomes. |
| first_indexed | 2024-03-07T23:04:44Z |
| format | Article |
| id | doaj.art-05e454fa36ce484e94f71ea2b89c7c48 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-07T23:04:44Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-05e454fa36ce484e94f71ea2b89c7c482024-02-22T05:19:22ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-02-011510.3389/fendo.2024.13329951332995Normal weight obesity is associated with lower AFC and adverse IVF outcomesYangcheng Yao0Yangcheng Yao1Wenjuan Liu2Xiqian Zhang3Nianjun Su4Li Huang5Yingqi Nong6Xiaomin Xiao7Fenghua Liu8Department of Obstetrics and Gynecology, The First Affiliated Hospital, Jinan University, Guangzhou, ChinaCenter for Reproductive Medicine, Guangdong Women and Children Hospital, Guangzhou, ChinaCenter for Reproductive Medicine, Guangdong Women and Children Hospital, Guangzhou, ChinaCenter for Reproductive Medicine, Guangdong Women and Children Hospital, Guangzhou, ChinaCenter for Reproductive Medicine, Guangdong Women and Children Hospital, Guangzhou, ChinaCenter for Reproductive Medicine, Guangdong Women and Children Hospital, Guangzhou, ChinaCenter for Reproductive Medicine, Guangdong Women and Children Hospital, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital, Jinan University, Guangzhou, ChinaCenter for Reproductive Medicine, Guangdong Women and Children Hospital, Guangzhou, ChinaBackgroundBody weight could be classified into underweight, normal weight and overweight according to percentage of body fat (%BF), and normal weight obesity (NWO) is defined as a normal BMI but a high %BF. While the impact of NWO in women fecundity remain unknow. Therefore, this study aimed to investigate the associations between %BF and reproductive outcomes among in vitro fertilization (IVF) women with normal BMI.MethodsA total of 469 women were included in this study and were classified into low %BF, normal %BF and high %BF according to previous study. Multivariate generalized regression models were employed to evaluate the associations of %BF with ovarian reserve parameters, IVF outcomes and early pregnancy outcomes. We further run sensitivity analyses by restricted the analysis to young women and those only with tubal factor, respectively.ResultsAbout 32.2% of normal BMI women were misclassified according %BF, with 16.4% of them were low %BF and 15.8% were high %BF. The high %BF group had significantly lower antral follicle count (AFC) than normal %BF groups, and the AFC showed a tendency of decrease as %BF increased. In sensitivity analysis in young women, high %BF group also had significantly lower number of good-quality embryos when compared to normal %BF groups. The results expanded to all IVF outcomes when analysis restricted to tubal factor women.ConclusionIn summary, misclassifications of body weight status based on BMI are common according to %BF, and NWO is associated with adverse reproductive outcomes.https://www.frontiersin.org/articles/10.3389/fendo.2024.1332995/fullbody mass indexpercentage of body fatnormal weight obesityantral follicle countreproductive outcomes |
| spellingShingle | Yangcheng Yao Yangcheng Yao Wenjuan Liu Xiqian Zhang Nianjun Su Li Huang Yingqi Nong Xiaomin Xiao Fenghua Liu Normal weight obesity is associated with lower AFC and adverse IVF outcomes Frontiers in Endocrinology body mass index percentage of body fat normal weight obesity antral follicle count reproductive outcomes |
| title | Normal weight obesity is associated with lower AFC and adverse IVF outcomes |
| title_full | Normal weight obesity is associated with lower AFC and adverse IVF outcomes |
| title_fullStr | Normal weight obesity is associated with lower AFC and adverse IVF outcomes |
| title_full_unstemmed | Normal weight obesity is associated with lower AFC and adverse IVF outcomes |
| title_short | Normal weight obesity is associated with lower AFC and adverse IVF outcomes |
| title_sort | normal weight obesity is associated with lower afc and adverse ivf outcomes |
| topic | body mass index percentage of body fat normal weight obesity antral follicle count reproductive outcomes |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1332995/full |
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