Disruption of 5-hydroxytryptamine 1A receptor and orexin receptor 1 heterodimer formation affects novel G protein-dependent signaling pathways and has antidepressant effects in vivo

Disruption of 5-hydroxytryptamine 1A receptor and orexin receptor 1 heterodimer formation affects novel G protein-dependent signaling pathways and has antidepressant effects in vivo

Abstract G protein-coupled receptor (GPCR) heterodimers are new targets for the treatment of depression. Increasing evidence supports the importance of serotonergic and orexin-producing neurons in numerous physiological processes, possibly via a crucial interaction between 5-hydroxytryptamine 1A rec...

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Bibliographic Details
Main Authors: Rumin Zhang, Dandan Li, Huiling Mao, Xiaonan Wei, MingDong Xu, Shengnan Zhang, Yunlu Jiang, Chunmei Wang, Qing Xin, Xiaoyu Chen, Guorong Li, Bingyuan Ji, Maocai Yan, Xin Cai, Bo Dong, Harpal S. Randeva, Chuanxin Liu, Jing Chen
Format: Article
Language:English
Published: Nature Publishing Group 2022-03-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-022-01886-1

Internet

https://doi.org/10.1038/s41398-022-01886-1

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