Post-COVID-19 illness and associations with sex and gender
Abstract Background Post-COVID-19 syndromes have associated with female sex, but the pathophysiological basis is uncertain. Aim There are sex differences in myocardial inflammation identified using cardiac magnetic resonance (CMR) in post-COVID-19 patients, and in patient reported health outcomes fo...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-023-03412-7 |
| _version_ | 1827635671536238592 |
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| author | Kenneth Mangion Andrew J. Morrow Robert Sykes Anna Kamdar Catherine Bagot George Bruce Paul Connelly Christian Delles Vivienne B. Gibson Lynsey Gillespie Pauline Hall Barrientos Vera Lennie Giles Roditi Naveed Sattar David Stobo Sarah Allwood-Spiers Alex McConnachie Colin Berry CISCO-19 investigators |
| author_facet | Kenneth Mangion Andrew J. Morrow Robert Sykes Anna Kamdar Catherine Bagot George Bruce Paul Connelly Christian Delles Vivienne B. Gibson Lynsey Gillespie Pauline Hall Barrientos Vera Lennie Giles Roditi Naveed Sattar David Stobo Sarah Allwood-Spiers Alex McConnachie Colin Berry CISCO-19 investigators |
| author_sort | Kenneth Mangion |
| collection | DOAJ |
| description | Abstract Background Post-COVID-19 syndromes have associated with female sex, but the pathophysiological basis is uncertain. Aim There are sex differences in myocardial inflammation identified using cardiac magnetic resonance (CMR) in post-COVID-19 patients, and in patient reported health outcomes following COVID-19 infection. Design This prospective study investigated the time-course of multiorgan injury in survivors of COVID-19 during convalescence. Methods Clinical information, blood biomarkers, and patient reported outcome measures were prospectively acquired at enrolment (visit 1) and 28–60 days post-discharge (visit 2). Chest computed tomography (CT) and CMR were performed at visit 2. Follow-up was carried out for serious adverse events, including death and rehospitalization. Results Sixty-nine (43%) of 159 patients recruited were female. During the index admission, females had a lower peak C-reactive protein (74 mg/l (21,163) versus 123 mg/l (70, 192) p = 0.008) and peak ferritin (229 μg/l (103, 551) versus 514 μg/l (228, 1122) p < 0.001). Using the Modified Lake-Louise criteria, females were more likely to have definite evidence of myocardial inflammation (54% (37/68) versus 33% (30/90) p = 0.003). At enrolment and 28–60 days post-discharge, enhanced illness perception, higher levels of anxiety and depression and lower predicted maximal oxygen utilization occurred more commonly in women. The mean (SD, range) duration of follow-up after hospital discharge was 450 (88) days (range 290, 627 days). Compared to men, women had lower rates of cardiovascular hospitalization (0% versus 8% (7/90); p = 0.018). Conclusions Women demonstrated worse patient reported outcome measures at index admission and 28–60 days follow-up though cardiovascular hospitalization was lower. |
| first_indexed | 2024-03-09T15:29:49Z |
| format | Article |
| id | doaj.art-05e4dc91da864d5d8769af428b579857 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-03-09T15:29:49Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-05e4dc91da864d5d8769af428b5798572023-11-26T12:16:58ZengBMCBMC Cardiovascular Disorders1471-22612023-08-0123111310.1186/s12872-023-03412-7Post-COVID-19 illness and associations with sex and genderKenneth Mangion0Andrew J. Morrow1Robert Sykes2Anna Kamdar3Catherine Bagot4George Bruce5Paul Connelly6Christian Delles7Vivienne B. Gibson8Lynsey Gillespie9Pauline Hall Barrientos10Vera Lennie11Giles Roditi12Naveed Sattar13David Stobo14Sarah Allwood-Spiers15Alex McConnachie16Colin Berry17CISCO-19 investigatorsSchool of Cardiovascular and Metabolic Health, University of GlasgowSchool of Cardiovascular and Metabolic Health, University of GlasgowSchool of Cardiovascular and Metabolic Health, University of GlasgowSchool of Cardiovascular and Metabolic Health, University of GlasgowDepartment of Haemostasis and Thrombosis, Glasgow Royal Infirmary, NHS Greater Glasgow and Clyde Health BoardDepartment of Medical Physics, NHS G Reater Glasgow and Clyde Health BoardSchool of Cardiovascular and Metabolic Health, University of GlasgowSchool of Cardiovascular and Metabolic Health, University of GlasgowDepartment of Haemostasis and Thrombosis, Glasgow Royal Infirmary, NHS Greater Glasgow and Clyde Health BoardProject Management Unit, Glasgow Clinical Research Facility, NHS Greater Glasgow and Clyde Health BoardDepartment of Medical Physics, NHS G Reater Glasgow and Clyde Health BoardDepartment of Cardiology, Aberdeen Royal InfirmaryDepartment of Radiology, NHS Greater Glasgow and Clyde Health BoardSchool of Cardiovascular and Metabolic Health, University of GlasgowDepartment of Radiology, NHS Greater Glasgow and Clyde Health BoardDepartment of Medical Physics, NHS G Reater Glasgow and Clyde Health BoardRobertson Centre for Biostatistics, School of Health and Wellbeing, University of GlasgowSchool of Cardiovascular and Metabolic Health, University of GlasgowAbstract Background Post-COVID-19 syndromes have associated with female sex, but the pathophysiological basis is uncertain. Aim There are sex differences in myocardial inflammation identified using cardiac magnetic resonance (CMR) in post-COVID-19 patients, and in patient reported health outcomes following COVID-19 infection. Design This prospective study investigated the time-course of multiorgan injury in survivors of COVID-19 during convalescence. Methods Clinical information, blood biomarkers, and patient reported outcome measures were prospectively acquired at enrolment (visit 1) and 28–60 days post-discharge (visit 2). Chest computed tomography (CT) and CMR were performed at visit 2. Follow-up was carried out for serious adverse events, including death and rehospitalization. Results Sixty-nine (43%) of 159 patients recruited were female. During the index admission, females had a lower peak C-reactive protein (74 mg/l (21,163) versus 123 mg/l (70, 192) p = 0.008) and peak ferritin (229 μg/l (103, 551) versus 514 μg/l (228, 1122) p < 0.001). Using the Modified Lake-Louise criteria, females were more likely to have definite evidence of myocardial inflammation (54% (37/68) versus 33% (30/90) p = 0.003). At enrolment and 28–60 days post-discharge, enhanced illness perception, higher levels of anxiety and depression and lower predicted maximal oxygen utilization occurred more commonly in women. The mean (SD, range) duration of follow-up after hospital discharge was 450 (88) days (range 290, 627 days). Compared to men, women had lower rates of cardiovascular hospitalization (0% versus 8% (7/90); p = 0.018). Conclusions Women demonstrated worse patient reported outcome measures at index admission and 28–60 days follow-up though cardiovascular hospitalization was lower.https://doi.org/10.1186/s12872-023-03412-7COVID-19Severe acute respiratory syndrome coronavirus-19SARS CoV-2Female sexMale sexMyocarditis |
| spellingShingle | Kenneth Mangion Andrew J. Morrow Robert Sykes Anna Kamdar Catherine Bagot George Bruce Paul Connelly Christian Delles Vivienne B. Gibson Lynsey Gillespie Pauline Hall Barrientos Vera Lennie Giles Roditi Naveed Sattar David Stobo Sarah Allwood-Spiers Alex McConnachie Colin Berry CISCO-19 investigators Post-COVID-19 illness and associations with sex and gender BMC Cardiovascular Disorders COVID-19 Severe acute respiratory syndrome coronavirus-19 SARS CoV-2 Female sex Male sex Myocarditis |
| title | Post-COVID-19 illness and associations with sex and gender |
| title_full | Post-COVID-19 illness and associations with sex and gender |
| title_fullStr | Post-COVID-19 illness and associations with sex and gender |
| title_full_unstemmed | Post-COVID-19 illness and associations with sex and gender |
| title_short | Post-COVID-19 illness and associations with sex and gender |
| title_sort | post covid 19 illness and associations with sex and gender |
| topic | COVID-19 Severe acute respiratory syndrome coronavirus-19 SARS CoV-2 Female sex Male sex Myocarditis |
| url | https://doi.org/10.1186/s12872-023-03412-7 |
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