Antimicrobial resistance of Pasteurella multocida type B isolates associated with acute septicemia in pigs and cattle in Spain
Abstract Background Pasteurella multocida is the etiological agent responsible for several diseases in a wide range of hosts around the world and thus, causes serious economic losses. Acute septicemia associated with capsular type B P. multocida has recently emerged in Europe and continuous outbreak...
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | BMC Veterinary Research |
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| Online Access: | http://link.springer.com/article/10.1186/s12917-020-02442-z |
| _version_ | 1819044203952340992 |
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| author | Inmaculada Cuevas Alfonso Carbonero David Cano Ignacio García-Bocanegra Manuel Ángel Amaro Carmen Borge |
| author_facet | Inmaculada Cuevas Alfonso Carbonero David Cano Ignacio García-Bocanegra Manuel Ángel Amaro Carmen Borge |
| author_sort | Inmaculada Cuevas |
| collection | DOAJ |
| description | Abstract Background Pasteurella multocida is the etiological agent responsible for several diseases in a wide range of hosts around the world and thus, causes serious economic losses. Acute septicemia associated with capsular type B P. multocida has recently emerged in Europe and continuous outbreaks of these acute processes have been described in Spain since they were first detected in pigs in 2009 and cattle in 2015. The scarcity of studies on the antimicrobial susceptibility of this capsular type of P. multocida and growing concern about the general increase of antimicrobial resistance mean that studies related to the performance of type B P. multocida against antibiotics are necessary to establish accurate treatments and to monitor antimicrobial resistances. Results Seventy-six isolates of P. multocida type B from pigs and cattle with acute septicemia were tested for susceptibility to 10 different antimicrobials. Bovine isolates were susceptible to all the antibiotics we tested except for lincomycin (94.4% of isolates were resistant). However, the antimicrobials we tested were less effective against swine isolates, of which none were susceptible to lincomycin. Furthermore, 29.3% swine isolates were resistant to tetracycline, 27.6% to penicillin, 20.7% to oxytetracycline, 17.3% to chloramphenicol, 15.5% to gentamicin, and 3.4% to enrofloxacin; no resistance to ceftiofur was detected. No multidrug resistant isolates were detected from cattle, while 25.86% of swine isolates were resistant to three or more antibiotic classes. Conclusions In this study, the lower resistance rates and multidrug resistant isolates reported for P. multocida type B derived from cattle compared to those isolated from pigs may be related to the increased use of antibiotics in the porcine industry in Spain. Lincomycin is not recommended for the treatment of acute septicemia in pigs or cattle, rather, the use of ceftiofur, enrofloxacin, or gentamicin is indicated as an emergency treatment in the early stages of disease; once the susceptibility results are known, the use of tetracyclines, penicillin, or chloramphenicol should be prioritized. The increase in multidrug resistant isolates and antimicrobial resistance rates indicates that more attention should be paid to prevention as well as the responsible use of antibiotics. |
| first_indexed | 2024-12-21T10:08:57Z |
| format | Article |
| id | doaj.art-05e58af520af44c3917659052db1e259 |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-12-21T10:08:57Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
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| series | BMC Veterinary Research |
| spelling | doaj.art-05e58af520af44c3917659052db1e2592022-12-21T19:07:45ZengBMCBMC Veterinary Research1746-61482020-06-011611910.1186/s12917-020-02442-zAntimicrobial resistance of Pasteurella multocida type B isolates associated with acute septicemia in pigs and cattle in SpainInmaculada Cuevas0Alfonso Carbonero1David Cano2Ignacio García-Bocanegra3Manuel Ángel Amaro4Carmen Borge5Department of Animal Health (AGR-149). Campus of International Agri-Food Excellence CeiA3, University of Córdoba, Rabanales University CampusDepartment of Animal Health (AGR-149). Campus of International Agri-Food Excellence CeiA3, University of Córdoba, Rabanales University CampusDepartment of Animal Health (AGR-149). Campus of International Agri-Food Excellence CeiA3, University of Córdoba, Rabanales University CampusDepartment of Animal Health (AGR-149). Campus of International Agri-Food Excellence CeiA3, University of Córdoba, Rabanales University CampusDepartment of Bromatology. Campus of International Agri-Food Excellence CeiA3, University of Córdoba, Rabanales University CampusDepartment of Animal Health (AGR-149). Campus of International Agri-Food Excellence CeiA3, University of Córdoba, Rabanales University CampusAbstract Background Pasteurella multocida is the etiological agent responsible for several diseases in a wide range of hosts around the world and thus, causes serious economic losses. Acute septicemia associated with capsular type B P. multocida has recently emerged in Europe and continuous outbreaks of these acute processes have been described in Spain since they were first detected in pigs in 2009 and cattle in 2015. The scarcity of studies on the antimicrobial susceptibility of this capsular type of P. multocida and growing concern about the general increase of antimicrobial resistance mean that studies related to the performance of type B P. multocida against antibiotics are necessary to establish accurate treatments and to monitor antimicrobial resistances. Results Seventy-six isolates of P. multocida type B from pigs and cattle with acute septicemia were tested for susceptibility to 10 different antimicrobials. Bovine isolates were susceptible to all the antibiotics we tested except for lincomycin (94.4% of isolates were resistant). However, the antimicrobials we tested were less effective against swine isolates, of which none were susceptible to lincomycin. Furthermore, 29.3% swine isolates were resistant to tetracycline, 27.6% to penicillin, 20.7% to oxytetracycline, 17.3% to chloramphenicol, 15.5% to gentamicin, and 3.4% to enrofloxacin; no resistance to ceftiofur was detected. No multidrug resistant isolates were detected from cattle, while 25.86% of swine isolates were resistant to three or more antibiotic classes. Conclusions In this study, the lower resistance rates and multidrug resistant isolates reported for P. multocida type B derived from cattle compared to those isolated from pigs may be related to the increased use of antibiotics in the porcine industry in Spain. Lincomycin is not recommended for the treatment of acute septicemia in pigs or cattle, rather, the use of ceftiofur, enrofloxacin, or gentamicin is indicated as an emergency treatment in the early stages of disease; once the susceptibility results are known, the use of tetracyclines, penicillin, or chloramphenicol should be prioritized. The increase in multidrug resistant isolates and antimicrobial resistance rates indicates that more attention should be paid to prevention as well as the responsible use of antibiotics.http://link.springer.com/article/10.1186/s12917-020-02442-zPasteurella multocidaType BAntimicrobial susceptibilityResistanceHemorrhagic septicemia |
| spellingShingle | Inmaculada Cuevas Alfonso Carbonero David Cano Ignacio García-Bocanegra Manuel Ángel Amaro Carmen Borge Antimicrobial resistance of Pasteurella multocida type B isolates associated with acute septicemia in pigs and cattle in Spain BMC Veterinary Research Pasteurella multocida Type B Antimicrobial susceptibility Resistance Hemorrhagic septicemia |
| title | Antimicrobial resistance of Pasteurella multocida type B isolates associated with acute septicemia in pigs and cattle in Spain |
| title_full | Antimicrobial resistance of Pasteurella multocida type B isolates associated with acute septicemia in pigs and cattle in Spain |
| title_fullStr | Antimicrobial resistance of Pasteurella multocida type B isolates associated with acute septicemia in pigs and cattle in Spain |
| title_full_unstemmed | Antimicrobial resistance of Pasteurella multocida type B isolates associated with acute septicemia in pigs and cattle in Spain |
| title_short | Antimicrobial resistance of Pasteurella multocida type B isolates associated with acute septicemia in pigs and cattle in Spain |
| title_sort | antimicrobial resistance of pasteurella multocida type b isolates associated with acute septicemia in pigs and cattle in spain |
| topic | Pasteurella multocida Type B Antimicrobial susceptibility Resistance Hemorrhagic septicemia |
| url | http://link.springer.com/article/10.1186/s12917-020-02442-z |
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