The Influence of the <i>CES1</i> Genotype on the Pharmacokinetics of Enalapril in Patients with Arterial Hypertension

The Influence of the <i>CES1</i> Genotype on the Pharmacokinetics of Enalapril in Patients with Arterial Hypertension

The angiotensin-converting enzyme inhibitor enalapril is hydrolysed to an active metabolite, enalaprilat, in the liver via carboxylesterase 1 (CES1). Previous studies show that variant rs71647871 in the <i>CES1</i> gene affects the pharmacokinetics of enalapril on liver samples as well a...

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Bibliographic Details
Main Authors: Anna Ikonnikova, Tatiana Rodina, Artem Dmitriev, Evgeniy Melnikov, Ruslan Kazakov, Tatiana Nasedkina
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Journal of Personalized Medicine
Subjects:
<i>CES1</i>
carboxylesterase 1
enalapril
SNP
pharmacogenetics
cardiology
Online Access:https://www.mdpi.com/2075-4426/12/4/580

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