Trace Elements in Febrile Seizure Compared to Febrile Children Admitted to an Academic Hospital in Iran, 2011
Background and Aim: Pathogenesis of Febrile Convulsion (FC) is unknown but some elements and genetic predispositions have been considered in the top list. This case-control study was designed to compare some trace elements in paediatrics who were admitted with FC and those in febrile ones withou...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2013-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/3478/34-%205548_E(C)_F(T)_PF1(VP)_PF2(Bo_PVP)_PFA(NC)_PF3(PP).pdf |
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| author | Sepideh Amouian Sakineh Mohammadian Naser Behnampour Mohsen Tizrou |
| author_facet | Sepideh Amouian Sakineh Mohammadian Naser Behnampour Mohsen Tizrou |
| author_sort | Sepideh Amouian |
| collection | DOAJ |
| description | Background and Aim: Pathogenesis of Febrile Convulsion (FC)
is unknown but some elements and genetic predispositions have
been considered in the top list. This case-control study was
designed to compare some trace elements in paediatrics who
were admitted with FC and those in febrile ones without seizure
attacks at an academic hospital in northeast of Iran.
Material and Methods: This case-control study was done from
June 2010 to July 2011 on 160 paediatrics (6-months to 5-years
old) who were diagnosed with FC and on 160 age-matched febrile
children as control group. Data on the age, gender, past history
of fever and convulsion, age at the first episode of seizure and
family history of FC were gathered by using a designed checklist.
Complete Blood Count (CBC), serum iron, Total Iron Binding
Capacity (TIBC), zinc, magnesium and calcium were tested after
taking informed consents from the parents. Serum levels of trace
elements were measured by a photometric method. Independent
t-test or non-parametric Mann-Whitney test were used to
compare means between two groups.
Results: There were no significant differences between the
cases and controls with regards to the gender or age. TIBC
and magnesium were lower in FC, but calcium, iron and zinc
were higher in FC as compared to those in the other group (not
significant).
Conclusions: So, it could be said that deficiency of trace elements
was not significantly related to febrile convulsion in our study and
it seemed that these tests were not necessary in FC cases. But
further investigations on other trace elements are needed. |
| first_indexed | 2024-12-21T04:15:05Z |
| format | Article |
| id | doaj.art-05e8a8d0afac47b0bc9004f8ebea0544 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-21T04:15:05Z |
| publishDate | 2013-10-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-05e8a8d0afac47b0bc9004f8ebea05442022-12-21T19:16:21ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2013-10-017102231223310.7860/JCDR/2013/5548.3478Trace Elements in Febrile Seizure Compared to Febrile Children Admitted to an Academic Hospital in Iran, 2011Sepideh Amouian0Sakineh Mohammadian1Naser Behnampour2Mohsen Tizrou3Assistant Professor, Department of Paediatric Neurology, Golestan University of Medical Science, Gorgan, Iran.Associate Professor of Paediatrics, Golestan University of Medical Science, Gorgan, Iran.PhD Student in Biostatistics, Haematology and Oncology Research Center, Golestan University of Medical Science, Gorgan, Iran.Assisstant of Paediatrics, Golestan University of Medical Science, Gorgan, Iran.Background and Aim: Pathogenesis of Febrile Convulsion (FC) is unknown but some elements and genetic predispositions have been considered in the top list. This case-control study was designed to compare some trace elements in paediatrics who were admitted with FC and those in febrile ones without seizure attacks at an academic hospital in northeast of Iran. Material and Methods: This case-control study was done from June 2010 to July 2011 on 160 paediatrics (6-months to 5-years old) who were diagnosed with FC and on 160 age-matched febrile children as control group. Data on the age, gender, past history of fever and convulsion, age at the first episode of seizure and family history of FC were gathered by using a designed checklist. Complete Blood Count (CBC), serum iron, Total Iron Binding Capacity (TIBC), zinc, magnesium and calcium were tested after taking informed consents from the parents. Serum levels of trace elements were measured by a photometric method. Independent t-test or non-parametric Mann-Whitney test were used to compare means between two groups. Results: There were no significant differences between the cases and controls with regards to the gender or age. TIBC and magnesium were lower in FC, but calcium, iron and zinc were higher in FC as compared to those in the other group (not significant). Conclusions: So, it could be said that deficiency of trace elements was not significantly related to febrile convulsion in our study and it seemed that these tests were not necessary in FC cases. But further investigations on other trace elements are needed.https://jcdr.net/articles/PDF/3478/34-%205548_E(C)_F(T)_PF1(VP)_PF2(Bo_PVP)_PFA(NC)_PF3(PP).pdffebrile convulsionzincmagnesiumcalcium |
| spellingShingle | Sepideh Amouian Sakineh Mohammadian Naser Behnampour Mohsen Tizrou Trace Elements in Febrile Seizure Compared to Febrile Children Admitted to an Academic Hospital in Iran, 2011 Journal of Clinical and Diagnostic Research febrile convulsion zinc magnesium calcium |
| title | Trace Elements in Febrile Seizure Compared to Febrile Children Admitted to an Academic Hospital in Iran, 2011 |
| title_full | Trace Elements in Febrile Seizure Compared to Febrile Children Admitted to an Academic Hospital in Iran, 2011 |
| title_fullStr | Trace Elements in Febrile Seizure Compared to Febrile Children Admitted to an Academic Hospital in Iran, 2011 |
| title_full_unstemmed | Trace Elements in Febrile Seizure Compared to Febrile Children Admitted to an Academic Hospital in Iran, 2011 |
| title_short | Trace Elements in Febrile Seizure Compared to Febrile Children Admitted to an Academic Hospital in Iran, 2011 |
| title_sort | trace elements in febrile seizure compared to febrile children admitted to an academic hospital in iran 2011 |
| topic | febrile convulsion zinc magnesium calcium |
| url | https://jcdr.net/articles/PDF/3478/34-%205548_E(C)_F(T)_PF1(VP)_PF2(Bo_PVP)_PFA(NC)_PF3(PP).pdf |
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