S135: CRISPR/CAS9 EDITING REVEALS DEPENDENCE OF HUMAN RICHTER SYNDROME AND MURINE CLL CELLS ON SIGNALS FROM B CELL RECEPTOR, CXCR4 RECEPTOR AND MACROPHAGES BUT NOT FROM TOLL-LIKE RECEPTORS IN VIVO - C. Martines; S. Chakraborty; V. Guastafierro; M. Vujovikj; T. Vaisitti; S. Deaglio; L. Laurenti; A. Dimovski; D. Efremov (HemaSphere, 2022)