Adsorption Properties and Hemolytic Activity of Porous Aluminosilicates in a Simulated Body Fluid
A study of the adsorption features of bovine serum albumin (BSA), sodium and potassium cations, and vitamin B1 by porous aluminosilicates with different structures in a medium simulating blood plasma was conducted. The objects of this study were synthetic silicates with a montmorillonite structure N...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | ChemEngineering |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2305-7084/6/5/78 |
| _version_ | 1797474270472830976 |
|---|---|
| author | Olga Yu. Golubeva Yulia A. Alikina Elena Yu. Brazovskaya Nadezhda M. Vasilenko |
| author_facet | Olga Yu. Golubeva Yulia A. Alikina Elena Yu. Brazovskaya Nadezhda M. Vasilenko |
| author_sort | Olga Yu. Golubeva |
| collection | DOAJ |
| description | A study of the adsorption features of bovine serum albumin (BSA), sodium and potassium cations, and vitamin B1 by porous aluminosilicates with different structures in a medium simulating blood plasma was conducted. The objects of this study were synthetic silicates with a montmorillonite structure Na<sub>2x</sub>(Al<sub>2(1-x)</sub>,Mg<sub>2x</sub>)Si<sub>4</sub>O<sub>10</sub>(OH)<sub>2</sub>·nH<sub>2</sub>O (x = 0.5, 0.9, 1), aluminosilicates of the kaolinite subgroup Al<sub>2</sub>Si<sub>2</sub>O<sub>5</sub>(OH)<sub>4</sub> with different particle morphologies (spherical, nanosponge, nanotubular, and platy), as well as framed silicates (Beta zeolite). An assessment of the possibility of using aluminosilicates as hemosorbents for extracorporeal blood purification was carried out. For this purpose, the sorption capacity of the samples both with respect to model medium molecular weight toxicants (BSA) and natural blood components—vitamins and alkaline cations—was investigated. The samples were also studied by X-ray diffraction, electron microscopy, and low-temperature nitrogen adsorption. The zeta potential of the sample’s surfaces and the distribution of active centers on their surfaces by the method of adsorption of acid-base indicators were determined. A hemolytic test was used to determine the ability of the studied samples to damage the membranes of eukaryotic cells. Langmuir, Freundlich, and Temkin models were used to describe the experimental BSA adsorption isotherms. To process the kinetic data, pseudo-first-order and pseudo-second-order adsorption models were used. It was found that porous aluminosilicates have a high sorption capacity for medium molecular weight pathogens (up to 12 times that of activated charcoal for some samples) and low toxicity to blood cells. Based on the obtained results, conclusions were made about the prospects for the development of new selective non-toxic hemosorbents based on synthetic aluminosilicates with a given set of properties. |
| first_indexed | 2024-03-09T20:27:47Z |
| format | Article |
| id | doaj.art-05eeecb73dde47c69e9d89c9e084b0b5 |
| institution | Directory Open Access Journal |
| issn | 2305-7084 |
| language | English |
| last_indexed | 2024-03-09T20:27:47Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | ChemEngineering |
| spelling | doaj.art-05eeecb73dde47c69e9d89c9e084b0b52023-11-23T23:29:34ZengMDPI AGChemEngineering2305-70842022-10-01657810.3390/chemengineering6050078Adsorption Properties and Hemolytic Activity of Porous Aluminosilicates in a Simulated Body FluidOlga Yu. Golubeva0Yulia A. Alikina1Elena Yu. Brazovskaya2Nadezhda M. Vasilenko3Laboratory of Silicate Sorbents Chemistry, Institute of Silicate Chemistry of Russian Academy of Sciences, Adm. Makarova Emb., 2, 199034 St. Petersburg, RussiaLaboratory of Silicate Sorbents Chemistry, Institute of Silicate Chemistry of Russian Academy of Sciences, Adm. Makarova Emb., 2, 199034 St. Petersburg, RussiaLaboratory of Silicate Sorbents Chemistry, Institute of Silicate Chemistry of Russian Academy of Sciences, Adm. Makarova Emb., 2, 199034 St. Petersburg, RussiaLaboratory of Silicate Sorbents Chemistry, Institute of Silicate Chemistry of Russian Academy of Sciences, Adm. Makarova Emb., 2, 199034 St. Petersburg, RussiaA study of the adsorption features of bovine serum albumin (BSA), sodium and potassium cations, and vitamin B1 by porous aluminosilicates with different structures in a medium simulating blood plasma was conducted. The objects of this study were synthetic silicates with a montmorillonite structure Na<sub>2x</sub>(Al<sub>2(1-x)</sub>,Mg<sub>2x</sub>)Si<sub>4</sub>O<sub>10</sub>(OH)<sub>2</sub>·nH<sub>2</sub>O (x = 0.5, 0.9, 1), aluminosilicates of the kaolinite subgroup Al<sub>2</sub>Si<sub>2</sub>O<sub>5</sub>(OH)<sub>4</sub> with different particle morphologies (spherical, nanosponge, nanotubular, and platy), as well as framed silicates (Beta zeolite). An assessment of the possibility of using aluminosilicates as hemosorbents for extracorporeal blood purification was carried out. For this purpose, the sorption capacity of the samples both with respect to model medium molecular weight toxicants (BSA) and natural blood components—vitamins and alkaline cations—was investigated. The samples were also studied by X-ray diffraction, electron microscopy, and low-temperature nitrogen adsorption. The zeta potential of the sample’s surfaces and the distribution of active centers on their surfaces by the method of adsorption of acid-base indicators were determined. A hemolytic test was used to determine the ability of the studied samples to damage the membranes of eukaryotic cells. Langmuir, Freundlich, and Temkin models were used to describe the experimental BSA adsorption isotherms. To process the kinetic data, pseudo-first-order and pseudo-second-order adsorption models were used. It was found that porous aluminosilicates have a high sorption capacity for medium molecular weight pathogens (up to 12 times that of activated charcoal for some samples) and low toxicity to blood cells. Based on the obtained results, conclusions were made about the prospects for the development of new selective non-toxic hemosorbents based on synthetic aluminosilicates with a given set of properties.https://www.mdpi.com/2305-7084/6/5/78aluminosilicateskaolinitemontmorillonitezeoliteshemosorbentsadsorption |
| spellingShingle | Olga Yu. Golubeva Yulia A. Alikina Elena Yu. Brazovskaya Nadezhda M. Vasilenko Adsorption Properties and Hemolytic Activity of Porous Aluminosilicates in a Simulated Body Fluid ChemEngineering aluminosilicates kaolinite montmorillonite zeolites hemosorbents adsorption |
| title | Adsorption Properties and Hemolytic Activity of Porous Aluminosilicates in a Simulated Body Fluid |
| title_full | Adsorption Properties and Hemolytic Activity of Porous Aluminosilicates in a Simulated Body Fluid |
| title_fullStr | Adsorption Properties and Hemolytic Activity of Porous Aluminosilicates in a Simulated Body Fluid |
| title_full_unstemmed | Adsorption Properties and Hemolytic Activity of Porous Aluminosilicates in a Simulated Body Fluid |
| title_short | Adsorption Properties and Hemolytic Activity of Porous Aluminosilicates in a Simulated Body Fluid |
| title_sort | adsorption properties and hemolytic activity of porous aluminosilicates in a simulated body fluid |
| topic | aluminosilicates kaolinite montmorillonite zeolites hemosorbents adsorption |
| url | https://www.mdpi.com/2305-7084/6/5/78 |
| work_keys_str_mv | AT olgayugolubeva adsorptionpropertiesandhemolyticactivityofporousaluminosilicatesinasimulatedbodyfluid AT yuliaaalikina adsorptionpropertiesandhemolyticactivityofporousaluminosilicatesinasimulatedbodyfluid AT elenayubrazovskaya adsorptionpropertiesandhemolyticactivityofporousaluminosilicatesinasimulatedbodyfluid AT nadezhdamvasilenko adsorptionpropertiesandhemolyticactivityofporousaluminosilicatesinasimulatedbodyfluid |