<b>2-Hydroxy-4-methoxybenzaldehyde: Larvicidal structure-activity studies</b>

<b>2-Hydroxy-4-methoxybenzaldehyde: Larvicidal structure-activity studies</b>

2-Hydroxy-4-methoxybenzaldehyde (<b>1</b>), a compound isolated from <i>Mondia whytei</i> (Hook) Skeels (Asclepiaceae) roots exhibited larvicidal activity (LD<sub>50</sub> 22 &mu;g/mL). A total of 18 other derivatives and closely related congeners revealed var...

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Bibliographic Details
Main Authors: Geoffrey M. Mahanga, Teresa O. Akenga, Wilber Lwande, Isaiah O. Ndiege
Format: Article
Language:English
Published: Chemical Society of Ethiopia 2005-06-01
Series:Bulletin of the Chemical Society of Ethiopia
Subjects:
2-Hydroxy-4-methoxybenzaldehyde
Larvicides
Structure-activity relationships
2-Hdroxybenzaldehyde
2-Benzyloxybenzaldehyde
Benzylphenyl ether <i>Anopheles gambiae</i>
Online Access:http://www.ajol.info/index.php/bcse/article/view/21110
Description
Summary:2-Hydroxy-4-methoxybenzaldehyde (<b>1</b>), a compound isolated from <i>Mondia whytei</i> (Hook) Skeels (Asclepiaceae) roots exhibited larvicidal activity (LD<sub>50</sub> 22 &mu;g/mL). A total of 18 other derivatives and closely related congeners revealed varying levels of larvicidal activity. Several closely related congeners, like 2-benzyloxy-4-methoxybenzaldehyde (<b>2</b>), 2-hydroxybenzaldehyde (<b>12</b>), 2-benzyloxybenzaldehyde (<b>3</b>) and benzylphenyl ether (<b>4</b>), showed marked improvement in activity (LD<sub>50</sub> 10, 9, 4.8, 1.2 &mu;g/mL, respectively) against <i>Anopheles gambiae</i> larvae. 2-Benzoyloxy-4-methoxybenzaldehyde (<b>5</b>) exhibited similar activity level (LD<sub>50</sub> 28 &mu;g/mL) as <b>1</b>.
ISSN:1011-3924
1726-801X

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