<b>2-Hydroxy-4-methoxybenzaldehyde: Larvicidal structure-activity studies</b>
2-Hydroxy-4-methoxybenzaldehyde (<b>1</b>), a compound isolated from <i>Mondia whytei</i> (Hook) Skeels (Asclepiaceae) roots exhibited larvicidal activity (LD<sub>50</sub> 22 μg/mL). A total of 18 other derivatives and closely related congeners revealed var...
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| Format: | Article |
| Language: | English |
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Chemical Society of Ethiopia
2005-06-01
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| Series: | Bulletin of the Chemical Society of Ethiopia |
| Subjects: | |
| Online Access: | http://www.ajol.info/index.php/bcse/article/view/21110 |
| _version_ | 1819231555752558592 |
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| author | Geoffrey M. Mahanga Teresa O. Akenga Wilber Lwande Isaiah O. Ndiege |
| author_facet | Geoffrey M. Mahanga Teresa O. Akenga Wilber Lwande Isaiah O. Ndiege |
| author_sort | Geoffrey M. Mahanga |
| collection | DOAJ |
| description | 2-Hydroxy-4-methoxybenzaldehyde (<b>1</b>), a compound isolated from <i>Mondia whytei</i> (Hook) Skeels (Asclepiaceae) roots exhibited larvicidal activity (LD<sub>50</sub> 22 μg/mL). A total of 18 other derivatives and closely related congeners revealed varying levels of larvicidal activity. Several closely related congeners, like 2-benzyloxy-4-methoxybenzaldehyde (<b>2</b>), 2-hydroxybenzaldehyde (<b>12</b>), 2-benzyloxybenzaldehyde (<b>3</b>) and benzylphenyl ether (<b>4</b>), showed marked improvement in activity (LD<sub>50</sub> 10, 9, 4.8, 1.2 μg/mL, respectively) against <i>Anopheles gambiae</i> larvae. 2-Benzoyloxy-4-methoxybenzaldehyde (<b>5</b>) exhibited similar activity level (LD<sub>50</sub> 28 μg/mL) as <b>1</b>. |
| first_indexed | 2024-12-23T11:46:50Z |
| format | Article |
| id | doaj.art-05f02b1491c04132872645d172c14d2d |
| institution | Directory Open Access Journal |
| issn | 1011-3924 1726-801X |
| language | English |
| last_indexed | 2024-12-23T11:46:50Z |
| publishDate | 2005-06-01 |
| publisher | Chemical Society of Ethiopia |
| record_format | Article |
| series | Bulletin of the Chemical Society of Ethiopia |
| spelling | doaj.art-05f02b1491c04132872645d172c14d2d2022-12-21T17:48:18ZengChemical Society of EthiopiaBulletin of the Chemical Society of Ethiopia1011-39241726-801X2005-06-011916168<b>2-Hydroxy-4-methoxybenzaldehyde: Larvicidal structure-activity studies</b>Geoffrey M. MahangaTeresa O. AkengaWilber LwandeIsaiah O. Ndiege2-Hydroxy-4-methoxybenzaldehyde (<b>1</b>), a compound isolated from <i>Mondia whytei</i> (Hook) Skeels (Asclepiaceae) roots exhibited larvicidal activity (LD<sub>50</sub> 22 μg/mL). A total of 18 other derivatives and closely related congeners revealed varying levels of larvicidal activity. Several closely related congeners, like 2-benzyloxy-4-methoxybenzaldehyde (<b>2</b>), 2-hydroxybenzaldehyde (<b>12</b>), 2-benzyloxybenzaldehyde (<b>3</b>) and benzylphenyl ether (<b>4</b>), showed marked improvement in activity (LD<sub>50</sub> 10, 9, 4.8, 1.2 μg/mL, respectively) against <i>Anopheles gambiae</i> larvae. 2-Benzoyloxy-4-methoxybenzaldehyde (<b>5</b>) exhibited similar activity level (LD<sub>50</sub> 28 μg/mL) as <b>1</b>.http://www.ajol.info/index.php/bcse/article/view/211102-Hydroxy-4-methoxybenzaldehydeLarvicidesStructure-activity relationships2-Hdroxybenzaldehyde2-BenzyloxybenzaldehydeBenzylphenyl ether <i>Anopheles gambiae</i> |
| spellingShingle | Geoffrey M. Mahanga Teresa O. Akenga Wilber Lwande Isaiah O. Ndiege <b>2-Hydroxy-4-methoxybenzaldehyde: Larvicidal structure-activity studies</b> Bulletin of the Chemical Society of Ethiopia 2-Hydroxy-4-methoxybenzaldehyde Larvicides Structure-activity relationships 2-Hdroxybenzaldehyde 2-Benzyloxybenzaldehyde Benzylphenyl ether <i>Anopheles gambiae</i> |
| title | <b>2-Hydroxy-4-methoxybenzaldehyde: Larvicidal structure-activity studies</b> |
| title_full | <b>2-Hydroxy-4-methoxybenzaldehyde: Larvicidal structure-activity studies</b> |
| title_fullStr | <b>2-Hydroxy-4-methoxybenzaldehyde: Larvicidal structure-activity studies</b> |
| title_full_unstemmed | <b>2-Hydroxy-4-methoxybenzaldehyde: Larvicidal structure-activity studies</b> |
| title_short | <b>2-Hydroxy-4-methoxybenzaldehyde: Larvicidal structure-activity studies</b> |
| title_sort | b 2 hydroxy 4 methoxybenzaldehyde larvicidal structure activity studies b |
| topic | 2-Hydroxy-4-methoxybenzaldehyde Larvicides Structure-activity relationships 2-Hdroxybenzaldehyde 2-Benzyloxybenzaldehyde Benzylphenyl ether <i>Anopheles gambiae</i> |
| url | http://www.ajol.info/index.php/bcse/article/view/21110 |
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