The emerging novel Middle East respiratory syndrome coronavirus: The “knowns” and “unknowns”
A novel lineage C betacoronavirus, originally named human coronavirus EMC/2012 (HCoV-EMC) and recently renamed Middle East respiratory syndrome coronavirus (MERS-CoV), that is phylogenetically closely related to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5, which we discov...
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| Format: | Article |
| Language: | English |
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Elsevier
2013-07-01
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| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664613001770 |
| _version_ | 1818152271727296512 |
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| author | Jasper Fuk-Woo Chan Susanna Kar-Pui Lau Patrick Chiu-Yat Woo |
| author_facet | Jasper Fuk-Woo Chan Susanna Kar-Pui Lau Patrick Chiu-Yat Woo |
| author_sort | Jasper Fuk-Woo Chan |
| collection | DOAJ |
| description | A novel lineage C betacoronavirus, originally named human coronavirus EMC/2012 (HCoV-EMC) and recently renamed Middle East respiratory syndrome coronavirus (MERS-CoV), that is phylogenetically closely related to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5, which we discovered in 2007 from bats in Hong Kong, has recently emerged in the Middle East to cause a severe acute respiratory syndrome (SARS)-like infection in humans. The first laboratory-confirmed case, which involved a 60-year-old man from Bisha, the Kingdom of Saudi Arabia (KSA), who died of rapidly progressive community-acquired pneumonia and acute renal failure, was announced by the World Health Organization (WHO) on September 23, 2012. Since then, a total of 70 cases, including 39 fatalities, have been reported in the Middle East and Europe. Recent clusters involving epidemiologically-linked household contacts and hospital contacts in the Middle East, Europe, and Africa strongly suggested possible human-to-human transmission. Clinical and laboratory research data generated in the past few months have provided new insights into the possible animal reservoirs, transmissibility, and virulence of MERS-CoV, and the optimal laboratory diagnostic options and potential antiviral targets for MERS-CoV-associated infection. |
| first_indexed | 2024-12-11T13:52:04Z |
| format | Article |
| id | doaj.art-05f06e90132b4ca1a9f05ac2b1ff3927 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-11T13:52:04Z |
| publishDate | 2013-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-05f06e90132b4ca1a9f05ac2b1ff39272022-12-22T01:04:13ZengElsevierJournal of the Formosan Medical Association0929-66462013-07-01112737238110.1016/j.jfma.2013.05.010The emerging novel Middle East respiratory syndrome coronavirus: The “knowns” and “unknowns”Jasper Fuk-Woo Chan0Susanna Kar-Pui Lau1Patrick Chiu-Yat Woo2State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, ChinaState Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, ChinaState Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, ChinaA novel lineage C betacoronavirus, originally named human coronavirus EMC/2012 (HCoV-EMC) and recently renamed Middle East respiratory syndrome coronavirus (MERS-CoV), that is phylogenetically closely related to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5, which we discovered in 2007 from bats in Hong Kong, has recently emerged in the Middle East to cause a severe acute respiratory syndrome (SARS)-like infection in humans. The first laboratory-confirmed case, which involved a 60-year-old man from Bisha, the Kingdom of Saudi Arabia (KSA), who died of rapidly progressive community-acquired pneumonia and acute renal failure, was announced by the World Health Organization (WHO) on September 23, 2012. Since then, a total of 70 cases, including 39 fatalities, have been reported in the Middle East and Europe. Recent clusters involving epidemiologically-linked household contacts and hospital contacts in the Middle East, Europe, and Africa strongly suggested possible human-to-human transmission. Clinical and laboratory research data generated in the past few months have provided new insights into the possible animal reservoirs, transmissibility, and virulence of MERS-CoV, and the optimal laboratory diagnostic options and potential antiviral targets for MERS-CoV-associated infection.http://www.sciencedirect.com/science/article/pii/S0929664613001770coronavirusEMChumanMiddle EastSARS |
| spellingShingle | Jasper Fuk-Woo Chan Susanna Kar-Pui Lau Patrick Chiu-Yat Woo The emerging novel Middle East respiratory syndrome coronavirus: The “knowns” and “unknowns” Journal of the Formosan Medical Association coronavirus EMC human Middle East SARS |
| title | The emerging novel Middle East respiratory syndrome coronavirus: The “knowns” and “unknowns” |
| title_full | The emerging novel Middle East respiratory syndrome coronavirus: The “knowns” and “unknowns” |
| title_fullStr | The emerging novel Middle East respiratory syndrome coronavirus: The “knowns” and “unknowns” |
| title_full_unstemmed | The emerging novel Middle East respiratory syndrome coronavirus: The “knowns” and “unknowns” |
| title_short | The emerging novel Middle East respiratory syndrome coronavirus: The “knowns” and “unknowns” |
| title_sort | emerging novel middle east respiratory syndrome coronavirus the knowns and unknowns |
| topic | coronavirus EMC human Middle East SARS |
| url | http://www.sciencedirect.com/science/article/pii/S0929664613001770 |
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