Minichromosome maintenance proteins in lung adenocarcinoma: Clinical significance and therapeutic targets
Lung cancer is the most common cause of cancer‐related death worldwide, accounting for 1.8 million deaths annually. Analysis of The Cancer Genome Atlas data showed that all members of the minichromosome maintenance (MCM) family (hexamers involved in DNA replication: MCM2‐MCM7) were upregulated in lu...
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| Format: | Article |
| Language: | English |
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Wiley
2023-09-01
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| Series: | FEBS Open Bio |
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| Online Access: | https://doi.org/10.1002/2211-5463.13681 |
| _version_ | 1797692980770897920 |
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| author | Kengo Tanigawa Yuya Tomioka Shunsuke Misono Shunichi Asai Naoko Kikkawa Yoko Hagihara Takayuki Suetsugu Hiromasa Inoue Keiko Mizuno Naohiko Seki |
| author_facet | Kengo Tanigawa Yuya Tomioka Shunsuke Misono Shunichi Asai Naoko Kikkawa Yoko Hagihara Takayuki Suetsugu Hiromasa Inoue Keiko Mizuno Naohiko Seki |
| author_sort | Kengo Tanigawa |
| collection | DOAJ |
| description | Lung cancer is the most common cause of cancer‐related death worldwide, accounting for 1.8 million deaths annually. Analysis of The Cancer Genome Atlas data showed that all members of the minichromosome maintenance (MCM) family (hexamers involved in DNA replication: MCM2‐MCM7) were upregulated in lung adenocarcinoma (LUAD) tissues. High expression of MCM4 (P = 0.0032), MCM5 (P = 0.0032), and MCM7 (P = 0.0110) significantly predicted 5‐year survival rates in patients with LUAD. Simurosertib (TAK‐931) significantly suppressed the proliferation of LUAD cells by inhibiting cell division cycle 7‐mediated MCM2 phosphorylation. This finding suggested that MCM2 might be a therapeutic target for LUAD. Moreover, analysis of the epigenetic regulation of MCM2 showed that miR‐139‐3p, miR‐378a‐5p, and miR‐2110 modulated MCM2 expression in LUAD cells. In patients with LUAD, understanding the role of these miRNAs may improve prognoses. |
| first_indexed | 2024-03-12T02:36:56Z |
| format | Article |
| id | doaj.art-05f078ab823e43088c262c888b2bfd21 |
| institution | Directory Open Access Journal |
| issn | 2211-5463 |
| language | English |
| last_indexed | 2024-03-12T02:36:56Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj.art-05f078ab823e43088c262c888b2bfd212023-09-04T13:56:57ZengWileyFEBS Open Bio2211-54632023-09-011391737175510.1002/2211-5463.13681Minichromosome maintenance proteins in lung adenocarcinoma: Clinical significance and therapeutic targetsKengo Tanigawa0Yuya Tomioka1Shunsuke Misono2Shunichi Asai3Naoko Kikkawa4Yoko Hagihara5Takayuki Suetsugu6Hiromasa Inoue7Keiko Mizuno8Naohiko Seki9Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences Kagoshima University JapanDepartment of Pulmonary Medicine, Graduate School of Medical and Dental Sciences Kagoshima University JapanDepartment of Pulmonary Medicine, Graduate School of Medical and Dental Sciences Kagoshima University JapanDepartment of Functional Genomics Chiba University Graduate School of Medicine JapanDepartment of Functional Genomics Chiba University Graduate School of Medicine JapanDepartment of Pulmonary Medicine, Graduate School of Medical and Dental Sciences Kagoshima University JapanDepartment of Pulmonary Medicine, Graduate School of Medical and Dental Sciences Kagoshima University JapanDepartment of Pulmonary Medicine, Graduate School of Medical and Dental Sciences Kagoshima University JapanDepartment of Pulmonary Medicine, Graduate School of Medical and Dental Sciences Kagoshima University JapanDepartment of Functional Genomics Chiba University Graduate School of Medicine JapanLung cancer is the most common cause of cancer‐related death worldwide, accounting for 1.8 million deaths annually. Analysis of The Cancer Genome Atlas data showed that all members of the minichromosome maintenance (MCM) family (hexamers involved in DNA replication: MCM2‐MCM7) were upregulated in lung adenocarcinoma (LUAD) tissues. High expression of MCM4 (P = 0.0032), MCM5 (P = 0.0032), and MCM7 (P = 0.0110) significantly predicted 5‐year survival rates in patients with LUAD. Simurosertib (TAK‐931) significantly suppressed the proliferation of LUAD cells by inhibiting cell division cycle 7‐mediated MCM2 phosphorylation. This finding suggested that MCM2 might be a therapeutic target for LUAD. Moreover, analysis of the epigenetic regulation of MCM2 showed that miR‐139‐3p, miR‐378a‐5p, and miR‐2110 modulated MCM2 expression in LUAD cells. In patients with LUAD, understanding the role of these miRNAs may improve prognoses.https://doi.org/10.1002/2211-5463.13681lung adenocarcinomaMCMmiR‐139‐3pmiR‐2110miR‐378a‐5psimurosertib |
| spellingShingle | Kengo Tanigawa Yuya Tomioka Shunsuke Misono Shunichi Asai Naoko Kikkawa Yoko Hagihara Takayuki Suetsugu Hiromasa Inoue Keiko Mizuno Naohiko Seki Minichromosome maintenance proteins in lung adenocarcinoma: Clinical significance and therapeutic targets FEBS Open Bio lung adenocarcinoma MCM miR‐139‐3p miR‐2110 miR‐378a‐5p simurosertib |
| title | Minichromosome maintenance proteins in lung adenocarcinoma: Clinical significance and therapeutic targets |
| title_full | Minichromosome maintenance proteins in lung adenocarcinoma: Clinical significance and therapeutic targets |
| title_fullStr | Minichromosome maintenance proteins in lung adenocarcinoma: Clinical significance and therapeutic targets |
| title_full_unstemmed | Minichromosome maintenance proteins in lung adenocarcinoma: Clinical significance and therapeutic targets |
| title_short | Minichromosome maintenance proteins in lung adenocarcinoma: Clinical significance and therapeutic targets |
| title_sort | minichromosome maintenance proteins in lung adenocarcinoma clinical significance and therapeutic targets |
| topic | lung adenocarcinoma MCM miR‐139‐3p miR‐2110 miR‐378a‐5p simurosertib |
| url | https://doi.org/10.1002/2211-5463.13681 |
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