Impact of Auditory Experience on the Structural Plasticity of the AIS in the Mouse Brainstem Throughout the Lifespan
Sound input critically influences the development and maintenance of neuronal circuits in the mammalian brain throughout life. We investigate the structural and functional plasticity of auditory neurons in response to various auditory experiences during development, adulthood, and aging. Using elect...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-10-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2019.00456/full |
| _version_ | 1818217616605446144 |
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| author | Eun Jung Kim Chenling Feng Fidel Santamaria Jun Hee Kim |
| author_facet | Eun Jung Kim Chenling Feng Fidel Santamaria Jun Hee Kim |
| author_sort | Eun Jung Kim |
| collection | DOAJ |
| description | Sound input critically influences the development and maintenance of neuronal circuits in the mammalian brain throughout life. We investigate the structural and functional plasticity of auditory neurons in response to various auditory experiences during development, adulthood, and aging. Using electrophysiology, computer simulation, and immunohistochemistry, we study the structural plasticity of the axon initial segment (AIS) in the medial nucleus of the trapezoid body (MNTB) from the auditory brainstem of the mice (either sex), in different ages and auditory environments. The structure and spatial location of the AIS of MNTB neurons depend on their functional topographic location along the tonotopic axis, aligning high- to low-frequency sound-responding neurons (HF or LF neurons). HF neurons dramatically undergo structural remodeling of the AIS throughout life. The AIS progressively shortens during development, is stabilized in adulthood, and becomes longer in aging. Sound inputs are critically associated with setting and maintaining AIS plasticity and tonotopy at various ages. Sound stimulation increases the excitability of auditory neurons. Computer simulation shows that modification of the AIS length, location, and diameter can affect firing properties of MNTB neurons in the developing brainstem. The adaptive capability of axonal structure in response to various auditory experiences at different ages suggests that sound input is important for the development and maintenance of the structural and functional properties of the auditory brain throughout life. |
| first_indexed | 2024-12-12T07:10:42Z |
| format | Article |
| id | doaj.art-05f0798fd81e4773aedd6048cb903c97 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-12T07:10:42Z |
| publishDate | 2019-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-05f0798fd81e4773aedd6048cb903c972022-12-22T00:33:37ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022019-10-011310.3389/fncel.2019.00456474426Impact of Auditory Experience on the Structural Plasticity of the AIS in the Mouse Brainstem Throughout the LifespanEun Jung Kim0Chenling Feng1Fidel Santamaria2Jun Hee Kim3The Department of Cellular and Integrative Physiology, UT Health San Antonio, San Antonio, TX, United StatesThe Department of Biology, University of Texas, San Antonio, TX, United StatesThe Department of Biology, University of Texas, San Antonio, TX, United StatesThe Department of Cellular and Integrative Physiology, UT Health San Antonio, San Antonio, TX, United StatesSound input critically influences the development and maintenance of neuronal circuits in the mammalian brain throughout life. We investigate the structural and functional plasticity of auditory neurons in response to various auditory experiences during development, adulthood, and aging. Using electrophysiology, computer simulation, and immunohistochemistry, we study the structural plasticity of the axon initial segment (AIS) in the medial nucleus of the trapezoid body (MNTB) from the auditory brainstem of the mice (either sex), in different ages and auditory environments. The structure and spatial location of the AIS of MNTB neurons depend on their functional topographic location along the tonotopic axis, aligning high- to low-frequency sound-responding neurons (HF or LF neurons). HF neurons dramatically undergo structural remodeling of the AIS throughout life. The AIS progressively shortens during development, is stabilized in adulthood, and becomes longer in aging. Sound inputs are critically associated with setting and maintaining AIS plasticity and tonotopy at various ages. Sound stimulation increases the excitability of auditory neurons. Computer simulation shows that modification of the AIS length, location, and diameter can affect firing properties of MNTB neurons in the developing brainstem. The adaptive capability of axonal structure in response to various auditory experiences at different ages suggests that sound input is important for the development and maintenance of the structural and functional properties of the auditory brain throughout life.https://www.frontiersin.org/article/10.3389/fncel.2019.00456/fullaxon initial segmentauditory brainstemMNTBauditory experiencemouse |
| spellingShingle | Eun Jung Kim Chenling Feng Fidel Santamaria Jun Hee Kim Impact of Auditory Experience on the Structural Plasticity of the AIS in the Mouse Brainstem Throughout the Lifespan Frontiers in Cellular Neuroscience axon initial segment auditory brainstem MNTB auditory experience mouse |
| title | Impact of Auditory Experience on the Structural Plasticity of the AIS in the Mouse Brainstem Throughout the Lifespan |
| title_full | Impact of Auditory Experience on the Structural Plasticity of the AIS in the Mouse Brainstem Throughout the Lifespan |
| title_fullStr | Impact of Auditory Experience on the Structural Plasticity of the AIS in the Mouse Brainstem Throughout the Lifespan |
| title_full_unstemmed | Impact of Auditory Experience on the Structural Plasticity of the AIS in the Mouse Brainstem Throughout the Lifespan |
| title_short | Impact of Auditory Experience on the Structural Plasticity of the AIS in the Mouse Brainstem Throughout the Lifespan |
| title_sort | impact of auditory experience on the structural plasticity of the ais in the mouse brainstem throughout the lifespan |
| topic | axon initial segment auditory brainstem MNTB auditory experience mouse |
| url | https://www.frontiersin.org/article/10.3389/fncel.2019.00456/full |
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