Teicoplanin non-susceptible coagulase-negative staphylococci in a large Australian healthcare network: Implications for treatment with vancomycin
<p><strong>Introduction and Objectives:</strong> Coagulase-negative staphylococci (CoNS) are relatively low in virulence but some are increasingly recognized as agents of clinically important infections. Glycopeptides are the drugs of choice for treatment of methicillin-resistant C...
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| Format: | Article |
| Language: | English |
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Sri Lankan Society for Microbiology
2017-05-01
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| Series: | Sri Lankan Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | https://sljid.sljol.info/articles/8116 |
| _version_ | 1797985006282342400 |
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| author | W. R. P. L. I. Wijesooriya D. N. Kotsanas T. M. Korman M Graham |
| author_facet | W. R. P. L. I. Wijesooriya D. N. Kotsanas T. M. Korman M Graham |
| author_sort | W. R. P. L. I. Wijesooriya |
| collection | DOAJ |
| description | <p><strong>Introduction and Objectives:</strong> Coagulase-negative staphylococci (CoNS) are relatively low in virulence but some are increasingly recognized as agents of clinically important infections. Glycopeptides are the drugs of choice for treatment of methicillin-resistant CoNS infections. Our aim was to analyse the susceptibility profile of CoNS in our healthcare network from 2010-2012.</p><p> </p><p><strong>Methods:</strong> All CoNS with susceptibility results were analysed as two groups; teicoplanin-susceptible (Teico-S) and non–susceptible (Teico-NS). Analysis included results of other antistaphylococcal antibiotic susceptibilities, sample type (sterile, non-sterile), species and patient location (intensive care unit (ICU) vs non-ICU).</p><p> </p><p><strong>Results:</strong> Of the 1510 CoNS isolates with susceptibility results, 109 (7.2%) were non-susceptible to teicoplanin. Teicoplanin non-susceptibility was associated with non-susceptibility to ≥ 3 antistaphylococcal-antibiotics, detected more frequently from sterile samples compared to non-sterile samples and from ICU compared to ward patients. <em>Staphylococcus epidermidis</em> was the most common species recovered and was more likely to be Teico-NS.</p><p> </p><p><strong>Conclusions:</strong> Teicoplanin non-susceptibility is associated with multi-resistance to ≥3 antistaphylococcal antibiotics. Clinicians should be aware that vancomycin resistance may be selected from Teico-NS strains.</p> |
| first_indexed | 2024-04-11T07:11:52Z |
| format | Article |
| id | doaj.art-05f2683f28dc4752bed3e3022ab54a35 |
| institution | Directory Open Access Journal |
| issn | 2012-8169 2448-9654 |
| language | English |
| last_indexed | 2024-04-11T07:11:52Z |
| publishDate | 2017-05-01 |
| publisher | Sri Lankan Society for Microbiology |
| record_format | Article |
| series | Sri Lankan Journal of Infectious Diseases |
| spelling | doaj.art-05f2683f28dc4752bed3e3022ab54a352022-12-22T04:38:08ZengSri Lankan Society for MicrobiologySri Lankan Journal of Infectious Diseases2012-81692448-96542017-05-0171101710.4038/sljid.v7i1.81165724Teicoplanin non-susceptible coagulase-negative staphylococci in a large Australian healthcare network: Implications for treatment with vancomycinW. R. P. L. I. Wijesooriya0D. N. Kotsanas1T. M. Korman2M Graham3University of KelaniyaMonash HealthMonash HealthMonash Health<p><strong>Introduction and Objectives:</strong> Coagulase-negative staphylococci (CoNS) are relatively low in virulence but some are increasingly recognized as agents of clinically important infections. Glycopeptides are the drugs of choice for treatment of methicillin-resistant CoNS infections. Our aim was to analyse the susceptibility profile of CoNS in our healthcare network from 2010-2012.</p><p> </p><p><strong>Methods:</strong> All CoNS with susceptibility results were analysed as two groups; teicoplanin-susceptible (Teico-S) and non–susceptible (Teico-NS). Analysis included results of other antistaphylococcal antibiotic susceptibilities, sample type (sterile, non-sterile), species and patient location (intensive care unit (ICU) vs non-ICU).</p><p> </p><p><strong>Results:</strong> Of the 1510 CoNS isolates with susceptibility results, 109 (7.2%) were non-susceptible to teicoplanin. Teicoplanin non-susceptibility was associated with non-susceptibility to ≥ 3 antistaphylococcal-antibiotics, detected more frequently from sterile samples compared to non-sterile samples and from ICU compared to ward patients. <em>Staphylococcus epidermidis</em> was the most common species recovered and was more likely to be Teico-NS.</p><p> </p><p><strong>Conclusions:</strong> Teicoplanin non-susceptibility is associated with multi-resistance to ≥3 antistaphylococcal antibiotics. Clinicians should be aware that vancomycin resistance may be selected from Teico-NS strains.</p>https://sljid.sljol.info/articles/8116coagulase-negative staphylococci, teicoplanin, vancomycin |
| spellingShingle | W. R. P. L. I. Wijesooriya D. N. Kotsanas T. M. Korman M Graham Teicoplanin non-susceptible coagulase-negative staphylococci in a large Australian healthcare network: Implications for treatment with vancomycin Sri Lankan Journal of Infectious Diseases coagulase-negative staphylococci, teicoplanin, vancomycin |
| title | Teicoplanin non-susceptible coagulase-negative staphylococci in a large Australian healthcare network: Implications for treatment with vancomycin |
| title_full | Teicoplanin non-susceptible coagulase-negative staphylococci in a large Australian healthcare network: Implications for treatment with vancomycin |
| title_fullStr | Teicoplanin non-susceptible coagulase-negative staphylococci in a large Australian healthcare network: Implications for treatment with vancomycin |
| title_full_unstemmed | Teicoplanin non-susceptible coagulase-negative staphylococci in a large Australian healthcare network: Implications for treatment with vancomycin |
| title_short | Teicoplanin non-susceptible coagulase-negative staphylococci in a large Australian healthcare network: Implications for treatment with vancomycin |
| title_sort | teicoplanin non susceptible coagulase negative staphylococci in a large australian healthcare network implications for treatment with vancomycin |
| topic | coagulase-negative staphylococci, teicoplanin, vancomycin |
| url | https://sljid.sljol.info/articles/8116 |
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