Возможности сфинктеросохраняющего лечения больных местно-распространенным первично-неоперабельным раком прямой кишки
The aim of this study was to compare results of sphincter-sparing operations (SSO) and abdominoperineal resections (APR) in patients undergoing combined treatment for unresectable locally-advanced rectal cancer.Methods. During September 2007 – January 2011 59 patients were enrolled. Original treatm...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
“ABV-press” Publishing house”, LLC
2015-02-01
|
| Series: | Тазовая хирургия и онкология |
| Subjects: | |
| Online Access: | https://ok.abvpress.ru/jour/article/view/61 |
| _version_ | 1797759229335961600 |
|---|---|
| author | Yu. A. Barsukov S. S. Gordeyev S. I. Tkachev |
| author_facet | Yu. A. Barsukov S. S. Gordeyev S. I. Tkachev |
| author_sort | Yu. A. Barsukov |
| collection | DOAJ |
| description | The aim of this study was to compare results of sphincter-sparing operations (SSO) and abdominoperineal resections (APR) in patients undergoing combined treatment for unresectable locally-advanced rectal cancer.Methods. During September 2007 – January 2011 59 patients were enrolled. Original treatment scheme (RF patent № 2414936) was developed including radiotherapy 40 Gy in 4 Gy fractions, capecitabine 650 mg/m2 bid per os days 1-22, oxaliplatin 50 mg/m2 iv days 3, 10, 17, local hyperthermia on days 8, 12, 15, 17, 2 applications of metronidazole 10 g/m2 per rectum in a polymeric composition. Surgery was carried out following 6–8 weeks. SSO were carried out in 36 patients, APR in 23 patients. Study endpoints included 2-year OS and DFS, local recurrence and distant metastases rate, postoperative complications rate.Results. No significant differences in survival were observed: 2-year OS was 93.2 and 85.6 % (log- rank test p = 0.157) for SSO and APR groups accordingly, 2-year DFS was 88 and 71.9 % (log-rank test p = 0.064). Four (11.1 %) patients in SSO group and 4 (17.4 %) patients in APR group (р = 0.5511) developed local recurrences, 4 (11.1 %) and 7 (30.4 %) (р = 0.1293) developed distant metastases. Postoperative complications rate was 27.8 % (n = 10) and 39.1 % (n = 9) (р = 0.5181) in SSO and APR groups accordingly.Conclusions. Sphincter-sparting surgery is justified for unresectable locally advanced rectal cancer when technically feasible. |
| first_indexed | 2024-03-12T18:41:24Z |
| format | Article |
| id | doaj.art-05f4763114ee42fcbd6d18842c86912c |
| institution | Directory Open Access Journal |
| issn | 2686-9594 |
| language | Russian |
| last_indexed | 2024-03-12T18:41:24Z |
| publishDate | 2015-02-01 |
| publisher | “ABV-press” Publishing house”, LLC |
| record_format | Article |
| series | Тазовая хирургия и онкология |
| spelling | doaj.art-05f4763114ee42fcbd6d18842c86912c2023-08-02T07:48:57Zrus“ABV-press” Publishing house”, LLCТазовая хирургия и онкология2686-95942015-02-0104212510.17650/2220-3478-2012-0-4-21-2555Возможности сфинктеросохраняющего лечения больных местно-распространенным первично-неоперабельным раком прямой кишкиYu. A. Barsukov0S. S. Gordeyev1S. I. Tkachev2N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowDepartment of Oncology, Faculty of Therapeutics, I.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowThe aim of this study was to compare results of sphincter-sparing operations (SSO) and abdominoperineal resections (APR) in patients undergoing combined treatment for unresectable locally-advanced rectal cancer.Methods. During September 2007 – January 2011 59 patients were enrolled. Original treatment scheme (RF patent № 2414936) was developed including radiotherapy 40 Gy in 4 Gy fractions, capecitabine 650 mg/m2 bid per os days 1-22, oxaliplatin 50 mg/m2 iv days 3, 10, 17, local hyperthermia on days 8, 12, 15, 17, 2 applications of metronidazole 10 g/m2 per rectum in a polymeric composition. Surgery was carried out following 6–8 weeks. SSO were carried out in 36 patients, APR in 23 patients. Study endpoints included 2-year OS and DFS, local recurrence and distant metastases rate, postoperative complications rate.Results. No significant differences in survival were observed: 2-year OS was 93.2 and 85.6 % (log- rank test p = 0.157) for SSO and APR groups accordingly, 2-year DFS was 88 and 71.9 % (log-rank test p = 0.064). Four (11.1 %) patients in SSO group and 4 (17.4 %) patients in APR group (р = 0.5511) developed local recurrences, 4 (11.1 %) and 7 (30.4 %) (р = 0.1293) developed distant metastases. Postoperative complications rate was 27.8 % (n = 10) and 39.1 % (n = 9) (р = 0.5181) in SSO and APR groups accordingly.Conclusions. Sphincter-sparting surgery is justified for unresectable locally advanced rectal cancer when technically feasible.https://ok.abvpress.ru/jour/article/view/61rectal cancerunresectable cancercombined treatmentsphincter-sparing treatment |
| spellingShingle | Yu. A. Barsukov S. S. Gordeyev S. I. Tkachev Возможности сфинктеросохраняющего лечения больных местно-распространенным первично-неоперабельным раком прямой кишки Тазовая хирургия и онкология rectal cancer unresectable cancer combined treatment sphincter-sparing treatment |
| title | Возможности сфинктеросохраняющего лечения больных местно-распространенным первично-неоперабельным раком прямой кишки |
| title_full | Возможности сфинктеросохраняющего лечения больных местно-распространенным первично-неоперабельным раком прямой кишки |
| title_fullStr | Возможности сфинктеросохраняющего лечения больных местно-распространенным первично-неоперабельным раком прямой кишки |
| title_full_unstemmed | Возможности сфинктеросохраняющего лечения больных местно-распространенным первично-неоперабельным раком прямой кишки |
| title_short | Возможности сфинктеросохраняющего лечения больных местно-распространенным первично-неоперабельным раком прямой кишки |
| title_sort | возможности сфинктеросохраняющего лечения больных местно распространенным первично неоперабельным раком прямой кишки |
| topic | rectal cancer unresectable cancer combined treatment sphincter-sparing treatment |
| url | https://ok.abvpress.ru/jour/article/view/61 |
| work_keys_str_mv | AT yuabarsukov vozmožnostisfinkterosohranâûŝegolečeniâbolʹnyhmestnorasprostranennympervičnoneoperabelʹnymrakomprâmojkiški AT ssgordeyev vozmožnostisfinkterosohranâûŝegolečeniâbolʹnyhmestnorasprostranennympervičnoneoperabelʹnymrakomprâmojkiški AT sitkachev vozmožnostisfinkterosohranâûŝegolečeniâbolʹnyhmestnorasprostranennympervičnoneoperabelʹnymrakomprâmojkiški |