Study on the Potential Toxicity of a Thymoquinone-Rich Fraction Nanoemulsion in Sprague Dawley Tats
Toxicological studies constitute an essential part of the effort in developing an herbal medicine into a drug product. A newly developed thymoquinone-rich fraction nanoemulsion (TQRFNE) has been prepared using a high pressure homogenizer. The purpose of this study was to investigate the potential ac...
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-06-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/18/7/7460 |
| _version_ | 1818549402202013696 |
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| author | Maznah Ismail Rozi Mahmud Mustapha Umar Imam Zaki Tubesha |
| author_facet | Maznah Ismail Rozi Mahmud Mustapha Umar Imam Zaki Tubesha |
| author_sort | Maznah Ismail |
| collection | DOAJ |
| description | Toxicological studies constitute an essential part of the effort in developing an herbal medicine into a drug product. A newly developed thymoquinone-rich fraction nanoemulsion (TQRFNE) has been prepared using a high pressure homogenizer. The purpose of this study was to investigate the potential acute toxicity of this nanoemulsion in Sprague Dawley rats. The acute toxicity studies were conducted as per the OECD guidelines 425, allowing for the use of test dose limit of 20 mL TQRFNE (containing 44.5 mg TQ)/kg. TQRFNE and distilled water (DW) as a control were administered orally to both sexes of rats on Day 0 and observed for 14 days. All the animals appeared normal, and healthy throughout the study. There was no observed mortality or any signs of toxicity during the experimental period. The effects of the TQRFNE and DW groups on general behavior, body weight, food and water consumption, relative organ weight, hematology, histopathology, and clinical biochemistry were measured. All the parameters measured were unaffected as compared to the control (DW) group. The administration of 20 mL TQRFNE /kg was not toxic after an acute exposure. |
| first_indexed | 2024-12-12T08:32:53Z |
| format | Article |
| id | doaj.art-05f6a33baaf849eab7487d607ba2b964 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-12T08:32:53Z |
| publishDate | 2013-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-05f6a33baaf849eab7487d607ba2b9642022-12-22T00:31:01ZengMDPI AGMolecules1420-30492013-06-011877460747210.3390/molecules18077460Study on the Potential Toxicity of a Thymoquinone-Rich Fraction Nanoemulsion in Sprague Dawley TatsMaznah IsmailRozi MahmudMustapha Umar ImamZaki TubeshaToxicological studies constitute an essential part of the effort in developing an herbal medicine into a drug product. A newly developed thymoquinone-rich fraction nanoemulsion (TQRFNE) has been prepared using a high pressure homogenizer. The purpose of this study was to investigate the potential acute toxicity of this nanoemulsion in Sprague Dawley rats. The acute toxicity studies were conducted as per the OECD guidelines 425, allowing for the use of test dose limit of 20 mL TQRFNE (containing 44.5 mg TQ)/kg. TQRFNE and distilled water (DW) as a control were administered orally to both sexes of rats on Day 0 and observed for 14 days. All the animals appeared normal, and healthy throughout the study. There was no observed mortality or any signs of toxicity during the experimental period. The effects of the TQRFNE and DW groups on general behavior, body weight, food and water consumption, relative organ weight, hematology, histopathology, and clinical biochemistry were measured. All the parameters measured were unaffected as compared to the control (DW) group. The administration of 20 mL TQRFNE /kg was not toxic after an acute exposure.http://www.mdpi.com/1420-3049/18/7/7460Sprague-Dawley ratsnanoemulsionthymoquinone rich fractionacute oral toxicityhistopathologyhematology |
| spellingShingle | Maznah Ismail Rozi Mahmud Mustapha Umar Imam Zaki Tubesha Study on the Potential Toxicity of a Thymoquinone-Rich Fraction Nanoemulsion in Sprague Dawley Tats Molecules Sprague-Dawley rats nanoemulsion thymoquinone rich fraction acute oral toxicity histopathology hematology |
| title | Study on the Potential Toxicity of a Thymoquinone-Rich Fraction Nanoemulsion in Sprague Dawley Tats |
| title_full | Study on the Potential Toxicity of a Thymoquinone-Rich Fraction Nanoemulsion in Sprague Dawley Tats |
| title_fullStr | Study on the Potential Toxicity of a Thymoquinone-Rich Fraction Nanoemulsion in Sprague Dawley Tats |
| title_full_unstemmed | Study on the Potential Toxicity of a Thymoquinone-Rich Fraction Nanoemulsion in Sprague Dawley Tats |
| title_short | Study on the Potential Toxicity of a Thymoquinone-Rich Fraction Nanoemulsion in Sprague Dawley Tats |
| title_sort | study on the potential toxicity of a thymoquinone rich fraction nanoemulsion in sprague dawley tats |
| topic | Sprague-Dawley rats nanoemulsion thymoquinone rich fraction acute oral toxicity histopathology hematology |
| url | http://www.mdpi.com/1420-3049/18/7/7460 |
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