Metformin Serves as a Novel Drug Treatment for Arterial Thrombosis: Inhibitory Mechanisms on Collagen-Induced Human Platelet Activation

Metformin Serves as a Novel Drug Treatment for Arterial Thrombosis: Inhibitory Mechanisms on Collagen-Induced Human Platelet Activation

Metformin is widely used as first-line medication for type 2 diabetes (T2D), the main disease comorbid with kidney disease, cardiovascular diseases (CVDs), and retinopathy. Platelets are crucial in platelet-dependent arterial thrombosis, which causes CVDs and cerebrovascular diseases. Research indic...

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Bibliographic Details
Main Authors:	Yi Chang, Wei-Chieh Huang, Chia-Yuan Hsu, Chih-Wei Hsia, Thanasekaran Jayakumar, Cheng-Ying Hsieh, Wan-Jung Lu, Chao-Chien Chang
Format:	Article
Language:	English
Published:	MDPI AG 2022-07-01
Series:	Applied Sciences
Subjects:	human platelets metformin p38 MAPK PLCγ2 pulmonary thrombosis PI3K/Akt/GSK3β
Online Access:	https://www.mdpi.com/2076-3417/12/15/7426

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