Localized T3 production modifies the transcriptome and promotes the hepatocyte-like lineage in iPSC-derived hepatic organoids

Localized T3 production modifies the transcriptome and promotes the hepatocyte-like lineage in iPSC-derived hepatic organoids

Thyroid hormone (TH) levels are low during development, and the deiodinases control TH signaling through tissue-specific activation or inactivation of TH. Here, we studied human induced pluripotent stem cell–derived (iPSC-derived) hepatic organoids and identified a robust induction of DIO2 expressio...

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Bibliographic Details
Main Authors: Jorge Hidalgo-Álvarez, Federico Salas-Lucia, Diana Vera Cruz, Tatiana L. Fonseca, Antonio C. Bianco
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-12-01
Series:JCI Insight
Subjects:
Endocrinology
Metabolism
Online Access:https://doi.org/10.1172/jci.insight.173780

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