Relation between high density lipoprotein particles concentration and cardiovascular events: a meta-analysis
Abstract Background Trails aimed at raising high density lipoprotein(HDL) cholesterol concentration failed to make better cardiovascular outcomes. HDL particles may be better biomarkers reflecting properties of HDL. This meta-analysis was conducted to evaluate the relation between blood HDL particle...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-06-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12944-018-0732-6 |
| _version_ | 1828911474176688128 |
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| author | YuJing Wu ZhiJuan Fan YaQiong Tian Shuang Liu ShuYe Liu |
| author_facet | YuJing Wu ZhiJuan Fan YaQiong Tian Shuang Liu ShuYe Liu |
| author_sort | YuJing Wu |
| collection | DOAJ |
| description | Abstract Background Trails aimed at raising high density lipoprotein(HDL) cholesterol concentration failed to make better cardiovascular outcomes. HDL particles may be better biomarkers reflecting properties of HDL. This meta-analysis was conducted to evaluate the relation between blood HDL particles level and cardiovascular events. Methods PubMed and other databases were searched for eligible studies and NewCastle-Ottawa Quality Assessment Scale(NOS) was used to assess the quality of included studies. A random or fixed-effect model was applied to calculate the pooled hazard ratio(HR). Results Twelve studies were finally included. The pooled HR(95%confidence interval) for per standard deviation(SD) increment and top quartile versus bottom quartile were 0.79(0.72,0.86) and 0.65(0.57,0.75), respectively. Subgroup analysis suggested that HR was significantly lower in subjects with a cardiovascular disease(CVD) history than that of people without established CVD. Subclass analysis indicated that HRs for per SD increment of small(0.85) and medium(0.84) HDL particles were significantly lower than that of large HDL particles(0.96). Conclusions HDL particle level in blood was inversely related to CVD events, indicating that HDL particles maybe a protective factor in patients with CVD, thus making HDL particles a potential biomarker and therapy target. |
| first_indexed | 2024-12-13T19:02:41Z |
| format | Article |
| id | doaj.art-05f90123cf7944368cfa1710a9013f24 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-13T19:02:41Z |
| publishDate | 2018-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-05f90123cf7944368cfa1710a9013f242022-12-21T23:34:38ZengBMCLipids in Health and Disease1476-511X2018-06-011711910.1186/s12944-018-0732-6Relation between high density lipoprotein particles concentration and cardiovascular events: a meta-analysisYuJing Wu0ZhiJuan Fan1YaQiong Tian2Shuang Liu3ShuYe Liu4Third Central Hospital of Tianjin, Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Artificial Cell, Artificial Cell Engineering Technology Research Center of Public Health MinistryThird Central Hospital of Tianjin, Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Artificial Cell, Artificial Cell Engineering Technology Research Center of Public Health MinistryThird Central Hospital of Tianjin, Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Artificial Cell, Artificial Cell Engineering Technology Research Center of Public Health MinistryThird Central Hospital of Tianjin, Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Artificial Cell, Artificial Cell Engineering Technology Research Center of Public Health MinistryThird Central Hospital of Tianjin, Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Artificial Cell, Artificial Cell Engineering Technology Research Center of Public Health MinistryAbstract Background Trails aimed at raising high density lipoprotein(HDL) cholesterol concentration failed to make better cardiovascular outcomes. HDL particles may be better biomarkers reflecting properties of HDL. This meta-analysis was conducted to evaluate the relation between blood HDL particles level and cardiovascular events. Methods PubMed and other databases were searched for eligible studies and NewCastle-Ottawa Quality Assessment Scale(NOS) was used to assess the quality of included studies. A random or fixed-effect model was applied to calculate the pooled hazard ratio(HR). Results Twelve studies were finally included. The pooled HR(95%confidence interval) for per standard deviation(SD) increment and top quartile versus bottom quartile were 0.79(0.72,0.86) and 0.65(0.57,0.75), respectively. Subgroup analysis suggested that HR was significantly lower in subjects with a cardiovascular disease(CVD) history than that of people without established CVD. Subclass analysis indicated that HRs for per SD increment of small(0.85) and medium(0.84) HDL particles were significantly lower than that of large HDL particles(0.96). Conclusions HDL particle level in blood was inversely related to CVD events, indicating that HDL particles maybe a protective factor in patients with CVD, thus making HDL particles a potential biomarker and therapy target.http://link.springer.com/article/10.1186/s12944-018-0732-6HDLParticleCardiovascular eventsMeta analysis |
| spellingShingle | YuJing Wu ZhiJuan Fan YaQiong Tian Shuang Liu ShuYe Liu Relation between high density lipoprotein particles concentration and cardiovascular events: a meta-analysis Lipids in Health and Disease HDL Particle Cardiovascular events Meta analysis |
| title | Relation between high density lipoprotein particles concentration and cardiovascular events: a meta-analysis |
| title_full | Relation between high density lipoprotein particles concentration and cardiovascular events: a meta-analysis |
| title_fullStr | Relation between high density lipoprotein particles concentration and cardiovascular events: a meta-analysis |
| title_full_unstemmed | Relation between high density lipoprotein particles concentration and cardiovascular events: a meta-analysis |
| title_short | Relation between high density lipoprotein particles concentration and cardiovascular events: a meta-analysis |
| title_sort | relation between high density lipoprotein particles concentration and cardiovascular events a meta analysis |
| topic | HDL Particle Cardiovascular events Meta analysis |
| url | http://link.springer.com/article/10.1186/s12944-018-0732-6 |
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