Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex

Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex

Summary: MBTD1, a H4K20me reader, has recently been identified as a component of the NuA4/TIP60 acetyltransferase complex, regulating gene expression and DNA repair. NuA4/TIP60 inhibits 53BP1 binding to chromatin through recognition of the H4K20me mark by MBTD1 and acetylation of H2AK15, blocking th...

Full description

Bibliographic Details
Main Authors: Heng Zhang, Maëva Devoucoux, Xiaosheng Song, Li Li, Gamze Ayaz, Harry Cheng, Wolfram Tempel, Cheng Dong, Peter Loppnau, Jacques Côté, Jinrong Min
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720303016

Similar Items

Similar Items